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CD72 Molecule (CD72) antibody (PE)

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Synonyms CD72c, Ly-19, Ly-32, Ly-m19, Lyb-2, CD72b, LYB2
(109), (33), (7)
(85), (56), (1), (1)
Clonality (Clone)
Monoclonal ()
(21), (15), (13), (3), (3), (3), (1)
Flow Cytometry (FACS)
(63), (55), (48), (23), (11), (9), (4), (3), (2), (2), (2), (2), (1)
Pubmed 4 references available
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Quantity 100 tests
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Normal human lymphocytes from a lymph node
Clone 3F3
Isotype IgG2b
Specificity This antibody reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.
Cross-Reactivity (Details) Species reactivity (tested):Human
Alternative Name CD72 (CD72 Antibody Abstract)
Background CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32
Gene ID 971
NCBI Accession NP_001773
UniProt P21854
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Dilute only prior to immediate use
Storage 4 °C
Storage Comment Store the antibody (undiluted) at 2-8 °C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.
Background publications Mizrahi, Markel, Porgador et al.: "CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." in: PLoS ONE, Vol. 2, Issue 9, pp. e818, 2007 (PubMed).

Kumanogoh, Shikina, Watanabe et al.: "Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment." in: International immunology, Vol. 17, Issue 10, pp. 1277-82, 2005 (PubMed).

Kumanogoh, Kikutani: "The CD100-CD72 interaction: a novel mechanism of immune regulation." in: Trends in immunology, Vol. 22, Issue 12, pp. 670-6, 2001 (PubMed).

Kumanogoh, Watanabe, Lee et al.: "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling." in: Immunity, Vol. 13, Issue 5, pp. 621-31, 2001 (PubMed).

Catalog No. ABIN616763
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