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Details for Product No. ABIN650622

Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 80-110), (Center) antibody

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Synonyms BIT1, PTH2, Bit1, CGI-147, A230072I16Rik, RGD1306819, wu:fj09f02, zgc:109954
»Alternatives AA 80-110, Center
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN650622
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This Bit1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-110 AA from the Central region of human Bit1.
Clone RB06095
Isotype Ig
Specificity This Bit1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88~118 amino acids from the Center region of human Bit1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Bit1
Background Adhesion to extracellular matrix regulates cell survival via integrin engagement and cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. A role for Bit1 (Bcl-2 inhibitor of transcription 1) has been identified in this process. Bit1 is a mitochondrial protein released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. Bit1-AES complexes may switch off a survival-promoting gene transcription program controlled by TLE. Apoptosis of Bit1/AES transfected cells is inhibited when cells are permitted to attach to fibronectin through the alpha-beta integrin, suggesting that the contribution of the Bit1-AES pathway to anoikis is regulated by integrins.
Synonyms: PTH 2, Bcl-2 inhibitor of transcription 1, Peptidyl-tRNA hydrolase 2, mitochondrial, PTH2
Molecular Weight 19194 DA
Gene ID 51651
UniProt Q9Y3E5
Research Area Cell Signaling, Cancer, Transcription Factors, Signaling, Neurology, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Jan, Matter, Pai et al.: "A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors." in: Cell, Vol. 116, Issue 5, pp. 751-62, 2004 (PubMed).

Martin, Vuori: "Regulation of Bcl-2 proteins during anoikis and amorphosis." in: Biochimica et biophysica acta, Vol. 1692, Issue 2-3, pp. 145-57, 2004 (PubMed).

Alternatives for antigen "Peptidyl-tRNA Hydrolase 2 (PTRH2)", type "Antibodies"
Hosts (50), (2)
Reactivities (50), (31), (23), (12), (12), (12), (1)
Applications (41), (18), (13), (9), (9), (8), (4), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (7), (4), (2), (2), (2), (1)