Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) (AA 217-245), (Center) antibody

Details for Product No. ABIN651123
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Antigen
Epitope
AA 217-245, Center
(7), (6), (2), (1), (1), (1)
Reactivity
Human
(123), (16), (16), (14), (12), (12), (4), (1)
Host
Rabbit
(94), (29)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(19), (16), (10), (7), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(94), (54), (21), (20), (18), (17), (16), (12), (11), (10), (10), (7), (4), (2), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN651123
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Immunogen This FCGR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 AA from the Central region of human FCGR1A.
Clone RB24072
Isotype Ig
Specificity This FCGR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acid 225-255 from the Central region of human FCGR1A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FCGR1A
Background FCGR1A encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.
Synonyms: CD_antigen=CD64, Flags: Precursor, Fc-gamma RI, FcRI, Fc-gamma RIA, FcgammaRIa, High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I,IGFR1, FCGR1, FCG1, FCGR1A
Molecular Weight 42632 DA
Gene ID 2209
UniProt P12314
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) (AA 217-245), (Center) antibody Western blot analysis of FCGR1A Antibody (Center) (ABIN651123) in NCI-H460 cell line lysates (35 µg/lane). FCGR1A (arrow) was detected using the purified polyclonal antibody.
anti-Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) (AA 217-245), (Center) antibody (2) FCGR1A Antibody (Center) (ABIN651123) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
anti-Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) (AA 217-245), (Center) antibody (3) FCGR1A Antibody (Center) (ABIN651123) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Poon, Hulett, Parish: "Histidine-rich glycoprotein is a novel plasma pattern recognition molecule that recruits IgG to facilitate necrotic cell clearance via FcgammaRI on phagocytes." in: Blood, Vol. 115, Issue 12, pp. 2473-82, 2010 (PubMed).

Jung, Reddy, Kang et al.: "Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 2, pp. 604-9, 2010 (PubMed).

Hulse, Reefer, Engelhard et al.: "Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor." in: The Journal of allergy and clinical immunology, Vol. 125, Issue 1, pp. 247-56.e1-8, 2010 (PubMed).

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