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Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) (N-Term), (AA 25-52) antibody

Details for Product No. ABIN651212
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Antigen
Synonyms LNCR2, NACHRA3, PAOD2, (a)3, A730007P14Rik, Acra-3, Acra3
Epitope
N-Term, AA 25-52
(12), (7), (4), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(44), (19), (19), (14), (14), (12), (12), (1)
Host
Rabbit
(46)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(37), (15), (15), (10), (6), (5), (2), (2)
Pubmed 1 reference available
Quantity 400 µL
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Catalog No. ABIN651212
291.50 $
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Immunogen This CHRNA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-52 AA from the N-terminal region of human CHRNA3.
Clone RB25608
Isotype Ig
Specificity This CHRNA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-60 amino acids from the N-terminal region of human CHRNA3.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CHRNA3
Background CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
Synonyms: Neuronal acetylcholine receptor subunit alpha-3,NACHRA3, CHRNA3
Pathways: Neuroactive ligand-receptor interaction
Molecular Weight 57480 Da
Gene ID 1136
UniProt P32297
Research Area Cell Signaling, Cell Structure, Protein Modifications, Cancer, Neurology
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) (N-Term), (AA 25-52) antibody Western blot analysis of CHRNA3 Antibody (N-term) (ABIN651212) in CEM cell line lysates (35 µg/lane).CHRNA3 (arrow) was detected using the purified polyclonal antibody.
anti-Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) (N-Term), (AA 25-52) antibody (2) CHRNA3 Antibody (N-term) (ABIN651212) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
Background publications Girard, Lou, Azzoli et al.: "Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 2, pp. 755-63, 2010 (PubMed).

Validation Images
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