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FOXP2 antibody (Forkhead Box P2) (AA 657-684)

Details for Product anti-FOXP2 Antibody No. ABIN651939, Supplier: Login to see
Antigen
  • spch1
  • cagh44
  • tnrc10
  • xlFoxP2
  • FOXP2
  • foxP2
  • foxP
  • Foxp2
  • CAGH44
  • SPCH1
  • TNRC10
  • 2810043D05Rik
  • AI449000
  • CAG-16
  • D0Kist7
  • RGD1559697
  • foxP2b
  • foxp2a
Epitope
AA 657-684, C-Term
36
17
8
5
4
3
2
2
2
1
1
Reactivity
Human, Mouse (Murine)
110
31
24
11
8
7
2
2
2
2
2
1
Host
Rabbit
50
39
23
1
Clonality (Clone)
Polyclonal ()
Conjugate
This FOXP2 antibody is un-conjugated
4
4
4
4
4
4
Application
Immunofluorescence (IF), Western Blotting (WB)
103
73
28
10
7
7
3
2
1
1
1
Supplier
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Immunogen This FOXP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 657-684 AA from the C-terminal region of human FOXP2.
Clone RB21207
Isotype Ig
Specificity This FOXP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 664-693 amino acids from the C-terminal region of human FOXP2.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FOXP2 (FOXP2 Antibody Abstract)
Background FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Synonyms: Forkhead box protein P2,FOXP2,TNRC10, CAGH44
Molecular Weight 79919 Da
Gene ID 93986
UniProt O15409
Research Area Translation Factors, Transcription Factors, Signaling, Chromatin, Cell Structure
Pathways
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FOXP2 antibody (Forkhead Box P2) (AA 657-684) (ABIN651939) FOXP2 Antibody (C-term) (ABIN651939) western blot analysis in mouse heart tissue lysa...
Immunofluorescence (IF) image for anti-FOXP2 antibody (Forkhead Box P2) (AA 657-684) (ABIN651939) Confocal immunofluorescent analysis of FOXP2 Antibody (C-term)(ABIN651939) with HepG2...
Product cited in: Fujita, Morita, Furuichi et al.: "Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 45, pp. 15688-703, 2012 (PubMed).

Background publications Lai, Fisher, Hurst et al.: "A forkhead-domain gene is mutated in a severe speech and language disorder." in: Nature, Vol. 413, Issue 6855, pp. 519-23, 2001 (PubMed).

Margolis, Abraham, Gatchell et al.: "cDNAs with long CAG trinucleotide repeats from human brain." in: Human genetics, Vol. 100, Issue 1, pp. 114-22, 1997 (PubMed).