Forkhead Box P2 (FOXP2) (C-Term), (AA 657-684) antibody

Details for Product No. ABIN651939
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms spch1, cagh44, tnrc10, xlFoxP2, FOXP2, foxP2, foxP, Foxp2, CAGH44, SPCH1, TNRC10, 2810043D05Rik, AI449000, CAG-16, D0Kist7, RGD1559697, foxP2b, foxp2a
Epitope
C-Term, AA 657-684
(14), (5), (5), (4), (3), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(48), (19), (10), (6), (4), (4), (1)
Host
Rabbit
(25), (14), (13), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(51), (30), (7), (7), (6), (2), (2)
Pubmed 2 references available
Quantity 400 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN651939
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This FOXP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 657-684 AA from the C-terminal region of human FOXP2.
Clone RB21207
Isotype Ig
Specificity This FOXP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 664-693 amino acids from the C-terminal region of human FOXP2.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FOXP2
Background FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Synonyms: Forkhead box protein P2,FOXP2,TNRC10, CAGH44
Molecular Weight 79919 Da
Gene ID 93986
UniProt O15409
Research Area Translation Factors, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Forkhead Box P2 (FOXP2) (C-Term), (AA 657-684) antibody FOXP2 Antibody (C-term) (ABIN651939) western blot analysis in mouse heart tissue lysates (15 µg/lane). This demonstrates the FOXP2 antibody detected FOXP2 protein (arrow).
anti-Forkhead Box P2 (FOXP2) (C-Term), (AA 657-684) antibody (2) Confocal immunofluorescent analysis of FOXP2 Antibody (C-term)(ABIN651939) with HepG2 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Background publications Margolis, Abraham, Gatchell et al.: "cDNAs with long CAG trinucleotide repeats from human brain." in: Human genetics, Vol. 100, Issue 1, pp. 114-22, 1997 (PubMed).

Lai, Fisher, Hurst et al.: "A forkhead-domain gene is mutated in a severe speech and language disorder." in: Nature, Vol. 413, Issue 6855, pp. 519-23, 2001 (PubMed).

Validation Images
Did you look for something else?
back to top