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Details for Product No. ABIN651939

Forkhead Box P2 (FOXP2) (C-Term), (AA 657-684) antibody

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Synonyms CAGH44, SPCH1, TNRC10, CAG-16, D0Kist7, AI449000, 2810043D05Rik, RGD1559697, FOXP2, cagh44, foxP2b, foxp2a, spch1, tnrc10, xlFoxP2, foxP2, foxP, Foxp2
»Alternatives C-Term, AA 657-684
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN651939
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This FOXP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 657-684 AA from the C-terminal region of human FOXP2.
Clone RB21207
Isotype Ig
Specificity This FOXP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 664-693 amino acids from the C-terminal region of human FOXP2.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FOXP2
Background FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Synonyms: Forkhead box protein P2,FOXP2,TNRC10, CAGH44
Molecular Weight 79919 Da
Gene ID 93986
UniProt O15409
Research Area Translation Factors, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Margolis, Abraham, Gatchell et al.: "cDNAs with long CAG trinucleotide repeats from human brain." in: Human genetics, Vol. 100, Issue 1, pp. 114-22, 1997 (PubMed).

Lai, Fisher, Hurst et al.: "A forkhead-domain gene is mutated in a severe speech and language disorder." in: Nature, Vol. 413, Issue 6855, pp. 519-23, 2001 (PubMed).

Alternatives for antigen "Forkhead Box P2 (FOXP2)", type "Antibodies"
Hosts (15), (15), (11)
Reactivities (35), (16), (10), (6), (4), (4), (1)
Applications (38), (24), (7), (5), (3), (2), (1)
Epitopes (9), (5), (4), (3), (2), (2), (1), (1)