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Details for Product No. ABIN652384

Hemopoietic Cell Kinase (HCK) (N-Term), (AA 131-156) antibody

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Antigen
Synonyms JTK9, p59Hck, p61Hck, AI849071, Bmk, Hctk, p56Hck, laloo, HCK, MGC107870
Epitope
»Alternatives N-Term, AA 131-156
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN652384
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This HCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-156 AA from the N-terminal region of human HCK.
Clone RB20667
Isotype Ig
Specificity This HCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the N-terminal region of human HCK.
Predicted Reactivity Mouse (Murine),Monkey,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HCK
Background HCK is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq].
Synonyms: Tyrosine-protein kinase HCK,HCK,
Molecular Weight 59600 DA
Gene ID 3055
UniProt P08631, NP_002101
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Kennah, Ringrose, Zhou et al.: "Identification of tyrosine kinase, HCK, and tumor suppressor, BIN1, as potential mediators of AHI-1 oncogene in primary and transformed CTCL cells." in: Blood, Vol. 113, Issue 19, pp. 4646-55, 2009 (PubMed).

Hassan, Suzu, Hiyoshi et al.: "Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms." in: Journal of cellular physiology, Vol. 221, Issue 2, pp. 458-68, 2009 (PubMed).

Alternatives for antigen "Hemopoietic Cell Kinase (HCK)", type "Antibodies"
Hosts (47), (16), (1)
Reactivities (63), (30), (26), (12), (12)
Applications (45), (29), (17), (10), (8), (7), (6), (4), (3), (3), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (5), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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