HCK antibody

Catalog No. ABIN969187

This Mouse Monoclonal antibody specifically detects HCK in ELISA and IHC. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for HCK antibody (ABIN969187)

Target: HCK (Hemopoietic Cell Kinase (HCK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HCK antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 3D12E10

Product Details anti-HCK Antibody

Purpose: HCK Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of HCK expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-HCK antibody (ABIN969187)

Schnoor: "What I learned in Europe...." in: Environmental science & technology, Vol. 41, Issue 3, pp. 667, (2007) (PubMed).

Selimoglu, Ertekin, Altinkaynak: "Hyper-CK-emia in pediatric celiac disease: prevalence and clinical importance." in: Journal of clinical gastroenterology, Vol. 41, Issue 7, pp. 667-70, (2007) (PubMed).

Target Details for HCK

Target: HCK (Hemopoietic Cell Kinase (HCK))

Alternative Name: HCK

Background: Hemopoietic cell kinase.The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

UniProt: P08631

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling