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Details for Product No. ABIN652999

Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (C-Term), (AA 482-508) antibody

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Antigen
Synonyms VDR, CP2B, CYP1, PDDR, VDD1, VDDR, VDDRI, CYP27B, P450c1, CYP1alpha, Cp2b, Cyp1, Cyp27b, Cyp40, Pddr, Vdd1, Vddr, VddrI, Vdr, cp2b, cyp1, cyp1alpha, cyp27b, p450c1, pddr, vdd1, vddr, vddri, vdr
Epitope
»Alternatives C-Term, AA 482-508
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 1 reference available
Catalog no. ABIN652999
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This CYP27B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-508 AA from the C-terminal region of human CYP27B1.
Clone RB16978
Isotype Ig
Specificity This CYP27B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 479~508 amino acids from the C-terminal region of human CYP27B1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CYP27B1
Background CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
Synonyms: Cytochrome P450VD1-alpha, Cytochrome P450C1 alpha, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, VD3 1A hydroxylase, 25-OHD-1 alpha-hydroxylase, Calcidiol 1-monooxygenase, Cytochrome p450 27B1, Cytochrome P450 subfamily XXVIIB polypeptide 1, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, CYP27B, CYP1ALPHA, CYP27B1
Pathways: Tuberculosis
Molecular Weight 56504 Da
Gene ID 1594
UniProt O15528
Research Area Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Simon, Munger, Xing Yang et al.: "Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 16, Issue 2, pp. 133-8, 2010 (PubMed).

Alternatives for antigen "Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1)", type "Antibodies"
Hosts (7), (1)
Reactivities (8)
Applications (8), (5), (4), (3), (1), (1)
Epitopes (7), (2), (2), (2), (1)
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