Xanthine Dehydrogenase (XDH) (N-Term), (AA 206-234) antibody

Details for Product No. ABIN653225
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Antigen
Synonyms XO, XDH, im:7146167, DDBDRAFT_0219626, DDBDRAFT_0230176, DDB_0219626, DDB_0230176, XOR, Xor, Xox-1, Xox1
Epitope
N-Term, AA 206-234
(8), (6), (1)
Reactivity
Human, Mouse (Murine)
(42), (29), (17), (16), (12)
Host
Rabbit
(55), (2), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(7), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(46), (29), (16), (14), (12), (10), (7), (7), (4), (3), (1), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN653225
291.50 $
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Immunogen This XDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 AA from the N-terminal region of human XDH.
Clone RB23202
Isotype Ig
Specificity This XDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213~242 amino acids from the N-terminal region of human XDH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name XDH
Background XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
Synonyms: Xanthine oxidoreductase, Xanthine oxidase, XO, Xanthine dehydrogenase, XD, Xanthine dehydrogenase/oxidase, XDHA, XDH
Molecular Weight 146424 DA
Gene ID 7498
UniProt P47989
Research Area Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Xanthine Dehydrogenase (XDH) (N-Term), (AA 206-234) antibody Western blot analysis of XDH Antibody (N-term) (ABIN653225) in mouse lung tissue lysates (35 µg/lane). XDH (arrow) was detected using the purified polyclonal antibody.
anti-Xanthine Dehydrogenase (XDH) (N-Term), (AA 206-234) antibody (2) Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with XDH Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Taibi, Carruba, Miceli et al.: "Estradiol decreases xanthine dehydrogenase enzyme activity and protein expression in non-tumorigenic and malignant human mammary epithelial cells." in: Journal of cellular biochemistry, Vol. 108, Issue 3, pp. 688-92, 2009 (PubMed).

Ross, Katzov-Eckert, Dubé et al.: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, 2009 (PubMed).

Validation Images
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