XDH antibody (N-Term)

Catalog No. ABIN955594

Product Details anti-XDH Antibody

Target: XDH (Xanthine Dehydrogenase (XDH))

Binding Specificity: AA 213-242, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XDH antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Xanthine dehydrogenase/oxidase (N-term).

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse.

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 213~242 amino acids from the N-terminal region of human XDH

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

References for anti-XDH antibody (ABIN955594)

Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

Target Details for XDH

Target: XDH (Xanthine Dehydrogenase (XDH))

Alternative Name: XDH (XDH Products)

Synonyms: XO antibody, XOR antibody, Xor antibody, Xox-1 antibody, Xox1 antibody, XDH antibody, im:7146167 antibody, DDBDRAFT_0219626 antibody, DDBDRAFT_0230176 antibody, DDB_0219626 antibody, DDB_0230176 antibody, xanthine dehydrogenase antibody, xanthine dehydrogenase/oxidase antibody, Xanthine dehydrogenase antibody, XDH antibody, Xdh antibody, xdh antibody, LOC576712 antibody, Trebr_1754 antibody

Background: XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.Synonyms: Xanthine dehydrogenase/oxidase

Gene ID: 7498

NCBI Accession: NP_000370

Pathways: Positive Regulation of Endopeptidase Activity