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T-Box 1 (TBX1) (AA 327-356), (C-Term) antibody

Details for Product No. ABIN653331, Supplier: Log in to see
Antigen
  • TBX1
  • dgs
  • tga
  • cafs
  • cthm
  • dgcr
  • dorv
  • vcfs
  • tbx1c
  • xtbx1
  • 3222402J11Rik
  • C85531
  • N4WBP3
  • CAFS
  • CTHM
  • DGCR
  • DGS
  • DORV
  • TBX1C
  • TGA
  • VCFS
  • mp:zf637-3-000616
  • zgc:136724
Alternatives
anti-Human T-Box 1 antibody for Immunohistochemistry
Epitope
AA 327-356, C-Term
32
15
4
3
2
1
1
1
1
1
1
1
1
Reactivity
Human
68
19
16
Host
Rabbit
64
4
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
55
28
27
24
12
11
10
2
2
1
1
Supplier
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Immunogen This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-356 AA from the C-terminal region of human TBX1.
Clone RB22154
Isotype Ig
Specificity This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334~364 amino acids from the C-terminal region of human TBX1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TBX1 (TBX1 Antibody Abstract)
Background TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms: Testis-specific T-box protein, T-box transcription factor TBX1, T-box protein 1, TBX1
Molecular Weight 43133 DA
Gene ID 6899
UniProt O43435
Research Area Transcription Factors, Signaling, Neurology
Pathways Retinoic Acid Receptor Signaling Pathway
Application Notes WB = 1:1000, IF = 1:10-50, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-T-Box 1 (TBX1) (AA 327-356), (C-Term) antibody (ABIN653331) Western blot analysis of TBX1 Antibody (C-term) (ABIN653331) in HepG2 cell line lysat...
Immunohistochemistry (IHC) image for anti-T-Box 1 (TBX1) (AA 327-356), (C-Term) antibody (ABIN653331) Formalin-fixed and paraffin-embedded human testis tissue reacted with TBX1 Antibody (...
Background publications Heike, Starr, Rieder et al.: "Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 1, pp. 54-63, 2010 (PubMed).

Beaujard, Chantot, Dubois et al.: "Atypical deletion of 22q11.2: detection using the FISH TBX1 probe and molecular characterization with high-density SNP arrays." in: European journal of medical genetics, Vol. 52, Issue 5, pp. 321-7, 2009 (PubMed).

Shalaby, Presneau, Idowu et al.: "Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 8, pp. 996-1005, 2009 (PubMed).

Yamagishi, Maeda, Hu et al.: "Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer." in: Genes & development, Vol. 17, Issue 2, pp. 269-81, 2003 (PubMed).