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T-Box 1 (TBX1) (AA 327-356), (C-Term) antibody

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Synonyms TBX1, dgs, tga, cafs, cthm, dgcr, dorv, vcfs, tbx1c, xtbx1, 3222402J11Rik, C85531, N4WBP3, CAFS, CTHM, DGCR, DGS, DORV, TBX1C, TGA, VCFS, mp:zf637-3-000616, zgc:136724
AA 327-356, C-Term
(32), (15), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(70), (19), (16)
(66), (4), (2)
Clonality (Clone)
Polyclonal ()
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(57), (29), (27), (25), (13), (11), (10), (3), (2), (1), (1)
Pubmed 4 references available
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Quantity 400 μL
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Availability Will be delivered in 2 to 4 Business Days
Immunogen This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-356 AA from the C-terminal region of human TBX1.
Clone RB22154
Isotype Ig
Specificity This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334~364 amino acids from the C-terminal region of human TBX1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TBX1 (TBX1 Antibody Abstract)
Background TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms: Testis-specific T-box protein, T-box transcription factor TBX1, T-box protein 1, TBX1
Molecular Weight 43133 DA
Gene ID 6899
UniProt O43435
Research Area Transcription Factors, Signaling, Neurology
Pathways Retinoic Acid Receptor Signaling Pathway
Application Notes WB = 1:1000, IF = 1:10-50, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-T-Box 1 (TBX1) (AA 327-356), (C-Term) antibody (ABIN653331) Western blot analysis of TBX1 Antibody (C-term) (ABIN653331) in HepG2 cell line lysat...
Immunohistochemistry (IHC) image for anti-T-Box 1 (TBX1) (AA 327-356), (C-Term) antibody (ABIN653331) Formalin-fixed and paraffin-embedded human testis tissue reacted with TBX1 Antibody (...
Background publications Heike, Starr, Rieder et al.: "Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 1, pp. 54-63, 2010 (PubMed).

Beaujard, Chantot, Dubois et al.: "Atypical deletion of 22q11.2: detection using the FISH TBX1 probe and molecular characterization with high-density SNP arrays." in: European journal of medical genetics, Vol. 52, Issue 5, pp. 321-7, 2009 (PubMed).

Shalaby, Presneau, Idowu et al.: "Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 8, pp. 996-1005, 2009 (PubMed).

Yamagishi, Maeda, Hu et al.: "Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer." in: Genes & development, Vol. 17, Issue 2, pp. 269-81, 2003 (PubMed).

Catalog No. ABIN653331
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