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TM173 (AA 311-340), (C-Term) antibody

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AA 311-340, C-Term
(18), (10), (7)
Human, Mouse (Murine)
(18), (1)
Clonality (Clone)
Polyclonal ()
(2), (2), (2), (2), (2), (2)
Flow Cytometry (FACS), Western Blotting (WB)
(16), (14), (14), (7), (1)
Pubmed 2 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This TM173 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 AA from the C-terminal region of human TM173.
Clone RB24462
Isotype Ig
Specificity This TM173 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318~348 amino acids from the C-terminal region of human TM173.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Synonyms: Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING, Transmembrane protein 173, STING, MITA, TMEM173
Molecular Weight 42193 DA
Gene ID 340061
UniProt Q86WV6
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TM173 (AA 311-340), (C-Term) antibody (ABIN653703) Western blot analysis of TM173 Antibody (C-term) (ABIN653703) in mouse spleen tissue ...
Flow Cytometry (FACS) image for anti-TM173 (AA 311-340), (C-Term) antibody (ABIN653703) TM173 Antibody (C-term) (ABIN653703) flow cytometric analysis of Hela cells (right hi...
Background publications Sun, Li, Chen et al.: "ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 21, pp. 8653-8, 2009 (PubMed).

Zhong, Zhang, Lei et al.: "The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA." in: Immunity, Vol. 30, Issue 3, pp. 397-407, 2009 (PubMed).

Catalog No. ABIN653703
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