ADAM Metallopeptidase Domain 19 (Adam19) (AA 207-236), (Center) antibody

Details for Product No. ABIN653772
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Antigen
Epitope
AA 207-236, Center
(7), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(41), (23), (21), (2), (2), (1), (1)
Host
Rabbit
(36), (2), (2), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(28), (16), (10), (9), (6), (5), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN653772
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Immunogen This ADAM19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-236 AA from the Central region of human ADAM19.
Clone RB17773
Isotype Ig
Specificity This ADAM19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215~245 amino acids from the Central region of human ADAM19.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ADAM19
Background This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction.
Synonyms: Metalloprotease and disintegrin dendritic antigen marker, MADDAM, Meltrin-beta, Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, FKSG34, MLTNB, ADAM19
Molecular Weight 105039 DA
Gene ID 8728
UniProt Q9H013
Research Area Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ADAM Metallopeptidase Domain 19 (Adam19) (AA 207-236), (Center) antibody Western blot analysis of ADAM19 Antibody (Center) (ABIN653772) in WiDr cell line lysates (35 µg/lane). ADAM19 (arrow) was detected using the purified polyclonal antibody.
anti-ADAM Metallopeptidase Domain 19 (Adam19) (AA 207-236), (Center) antibody (2) ADAM19 Antibody (Center) (ABIN653772) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
anti-ADAM Metallopeptidase Domain 19 (Adam19) (AA 207-236), (Center) antibody (3) ADAM19 Antibody (Center) (ABIN653772) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Tanabe, Hotoda, Sasagawa et al.: "ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells." in: Biochemical and biophysical research communications, Vol. 352, Issue 1, pp. 111-7, 2006 (PubMed).

Hancock, Eijgelsheim, Wilk et al.: "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function." in: Nature genetics, Vol. 42, Issue 1, pp. 45-52, 2009 (PubMed).

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