gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (C-Term), (AA 861-890) antibody

Details for Product No. ABIN654172
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Antigen
Epitope
C-Term, AA 861-890
(20), (20), (17), (13), (11), (7), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(95), (91), (65), (42), (41), (30), (24), (12), (5), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(99), (29), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(91), (45), (40), (27), (21), (16), (11), (4), (1)
Pubmed 1 reference available
Quantity 400 µL
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Catalog No. ABIN654172
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Immunogen This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 AA from the C-terminal region of human GABBR2.
Clone RB24610
Isotype Ig
Specificity This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 868-898 amino acids from the C-terminal region of human GABBR2.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name GABBR2
Background The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
Synonyms: Gamma-aminobutyric acid type B receptor subunit 2,GABBR2,GPR51, GPRC3B
Molecular Weight 105821 DA
Gene ID 9568
NCBI Accession NP_005449
UniProt O75899
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (C-Term), (AA 861-890) antibody GABBR2 antibody (C-term) (ABIN654172) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
Background publications Oblak, Gibbs, Blatt: "Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism." in: Journal of neurochemistry, Vol. 114, Issue 5, pp. 1414-23, 2010 (PubMed).

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