GABBR2 antibody (AA 319-483)

Catalog No. ABIN1724937

Cited in 1 publication. The Mouse Monoclonal anti-GABBR2 antibody (Clone 5G7F7) (ABIN1724937) specifically detects GABBR2 in IHC, ELISA and ICC. The antibody is reactive with Human samples.

Quick Overview for GABBR2 antibody (AA 319-483) (ABIN1724937)

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GABBR2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Clone: 5G7F7

Product Details anti-GABBR2 Antibody

Binding Specificity: AA 319-483

Purpose: GABBR2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human GABBR2 (AA: 319-483) expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-GABBR2 antibody (ABIN1724937)

Balasubramanian, Fam, Hall: "GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function." in: The Journal of biological chemistry, Vol. 282, Issue 6, pp. 4162-71, (2007) (PubMed).

Target Details for GABBR2

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Alternative Name: GABBR2

Background: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

Molecular Weight: 105.8 kDa

Gene ID: 9568

UniProt: O75899

Pathways: cAMP Metabolic Process