APG8a/b (MAP1LC3A/B) (AA 100-125), (cleaved) antibody

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AA 100-125, cleaved
Human, Mouse (Murine)
Clonality (Clone)
Polyclonal ()
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Immunogen This Cleaved-APG8a/b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-125 AA from human Cleaved-APG8a/b.
Clone RB28610
Isotype Ig
Specificity This Cleaved-APG8a/b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from human Cleaved-APG8a/b.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
Synonyms: MAP1LC3B,Microtubule-associated proteins 1A/1B light chain 3B,MAP1ALC3
Molecular Weight 14688 DA
Gene ID 81631
NCBI Accession NP_073729
UniProt Q9GZQ8
Research Area Cell Structure, Autophagy
Application Notes IF = 1:100, WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.29 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-APG8a/b (MAP1LC3A/B) (AA 100-125), (cleaved) antibody (ABIN654605) Cleaved-APG8a/b antibody (MAP1LC3A/B) (ABIN654605) immunohistochemistry analysis in f...
Background publications Kirkin, Lamark, Sou, Bjørkøy, Nunn, Bruun, Shvets, McEwan, Clausen, Wild, Bilusic, Theurillat, Øvervatn, Ishii, Elazar, Komatsu, Dikic, Johansen: "A role for NBR1 in autophagosomal degradation of ubiquitinated substrates." in: Molecular cell, Vol. 33, Issue 4, pp. 505-16, 2009 (PubMed).

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