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MAP1LC3A/B antibody (AA 25-121)

Reactivity: Human, Rat FACS, IHC (p), ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386128
  • Target See all MAP1LC3A/B products
    MAP1LC3A/B (MAP1LC3A,B)
    Binding Specificity
    • 15
    • 15
    • 1
    • 1
    • 1
    AA 25-121
    Reactivity
    • 32
    • 30
    • 16
    • 15
    Human, Rat
    Host
    • 32
    Rabbit
    Clonality
    • 32
    Polyclonal
    Conjugate
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This MAP1LC3A/B antibody is un-conjugated
    Application
    • 17
    • 13
    • 13
    • 13
    • 6
    • 5
    • 3
    • 2
    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Dog,Cow,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MAP LC3 Alpha
    Isotype
    IgG
  • Application Notes
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    MAP1LC3A/B (MAP1LC3A,B)
    Alternative Name
    MAP 1A/1B LC3 Alpha/Beta (MAP1LC3A/B Products)
    Synonyms
    ATG8F antibody, LC3B antibody, MAP1A/1BLC3 antibody, MAP1LC3B-a antibody, Map1lc3 antibody, Mpl3 antibody, zbs559 antibody, 1010001C15Rik antibody, Atg8 antibody, LC3b antibody, microtubule associated protein 1 light chain 3 beta antibody, microtubule-associated protein 1 light chain 3 beta antibody, MAP1LC3B antibody, Map1lc3b antibody
    Background

    Synonyms: Microtubule-associated proteins 1A/B light chain 3A, Microtubule-associated proteins 1A/B light chain 3B, Microtubule-associated proteins 1Beta light chain 3A, Microtubule-associated proteins 1Beta light chain 3A, MAP1B LC3 A, MAP LC3 Beta, MAP-LC3 Beta, MAP1 light chain 3-like protein 1.MAP1LC3B.MLP3A_HUMAN

    Background: Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3 Beta) and MAP-light chain 3 alpha (MAP-LC3 alpha) are subunits of both MAP1A and MAP1B. MAP-LC3M Beta, a homolog of Apg8p, is essential for autophagy and associated to the autophagosome membranes after processing. Two forms of LC3 Beta, the cytosolic LC3-I and the membrane-bound LC3-II, are produced post-translationally. LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by the conversion of a fraction of LC3-I into LC3-II. LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3? untranslated region of fibronectin mRNA. This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation. MAP LC3 Beta may also be involved in formation of autophagosomal vacuoles. It is expressed primarily in heart, testis, brain and skeletal muscle.

    Gene ID
    54901, 84557
    UniProt
    Q9H492, Q9GZQ8
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