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Details for Product No. ABIN654688

Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 586-613), (Center) antibody

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Antigen
Synonyms BTBD26, BTKI, RP1-93K22.1, AA409502, mKIAA1417, 5430411K16Rik, MGC82217, IBTK, fi40c08, wu:fi40c08, DKFZp468J085
Epitope
»Alternatives AA 586-613, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN654688
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 AA from the Central region of human IBTK.
Clone RB24652
Isotype Ig
Specificity This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-617 amino acids from the Central region of human IBTK.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IBTK
Background The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
Synonyms: Inhibitor of Bruton tyrosine kinase,IBTK,BTKI, KIAA1417
Molecular Weight 150528 DA
Gene ID 25998
UniProt NP_056340.2, Q9P2D0
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Spatuzza, Schiavone, Di Salle et al.: "Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk." in: Nucleic acids research, Vol. 36, Issue 13, pp. 4402-16, 2008 (PubMed).

Alternatives for antigen "Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK)", type "Antibodies"
Hosts (17), (1)
Reactivities (18), (12), (12), (12)
Applications (10), (7), (6), (5), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (1), (1), (1), (1), (1)
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