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Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 586-613), (Center) antibody

Details for Product No. ABIN654688
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Antigen
Epitope
AA 586-613, Center
(8), (2), (1), (1), (1)
Reactivity
Human
(24), (12), (12), (12)
Host
Rabbit
(23), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(14), (10), (9), (8), (6), (5), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN654688
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Immunogen This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 AA from the Central region of human IBTK.
Clone RB24652
Isotype Ig
Specificity This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-617 amino acids from the Central region of human IBTK.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IBTK
Background The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
Synonyms: Inhibitor of Bruton tyrosine kinase,IBTK,BTKI, KIAA1417
Molecular Weight 150528 DA
Gene ID 25998
UniProt NP_056340.2, Q9P2D0
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 586-613), (Center) antibody IBTK Antibody (Center) (ABIN654688) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Spatuzza, Schiavone, Di Salle et al.: "Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk." in: Nucleic acids research, Vol. 36, Issue 13, pp. 4402-16, 2008 (PubMed).

Validation Images
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