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Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 586-613), (Center) antibody

Details for Product No. ABIN654688, Supplier: Log in to see
Antigen
  • IBTK
  • fi40c08
  • wu:fi40c08
  • DKFZp468J085
  • BTBD26
  • BTKI
  • RP1-93K22.1
  • 5430411K16Rik
  • AA409502
  • mKIAA1417
Epitope
AA 586-613, Center
16
7
7
3
2
1
1
1
1
Reactivity
Human
24
Host
Rabbit
21
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
22
17
14
14
2
1
1
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Immunogen This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-613 AA from the Central region of human IBTK.
Clone RB24652
Isotype Ig
Specificity This IBTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-617 amino acids from the Central region of human IBTK.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IBTK (IBTK Antibody Abstract)
Background The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
Synonyms: Inhibitor of Bruton tyrosine kinase,IBTK,BTKI, KIAA1417
Molecular Weight 150528 DA
Gene ID 25998
NCBI Accession NP_056340
UniProt Q9P2D0
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Flow Cytometry (FACS) image for anti-Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (AA 586-613), (Center) antibody (ABIN654688) IBTK Antibody (Center) (ABIN654688) flow cytometric analysis of MDA-MB435 cells (righ...
Background publications Spatuzza, Schiavone, Di Salle et al.: "Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk." in: Nucleic acids research, Vol. 36, Issue 13, pp. 4402-16, 2008 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).