IBTK antibody (Middle Region)

Catalog No. ABIN952814

Product Details anti-IBTK Antibody

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Binding Specificity: AA 589-617, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IBTK antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human IBTK / BTKI (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 589-617 amino acids from the Central region of human IBTK / BTKI

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IBTK

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Alternative Name: IBTK / BTKI (IBTK Products)

Synonyms: IBTK antibody, fi40c08 antibody, wu:fi40c08 antibody, DKFZp468J085 antibody, BTBD26 antibody, BTKI antibody, RP1-93K22.1 antibody, 5430411K16Rik antibody, AA409502 antibody, mKIAA1417 antibody, inhibitor of Bruton tyrosine kinase antibody, inhibitor of Bruton agammaglobulinemia tyrosine kinase antibody, inhibitor of Bruton tyrosine kinase L homeolog antibody, IBTK antibody, ibtk antibody, Ibtk antibody, ibtk.L antibody

Background: The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.Synonyms: Inhibitor of Bruton tyrosine kinase, KIAA1417

Molecular Weight: 150528 Da

Gene ID: 25998

NCBI Accession: NP_056340