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Inhibin, beta A (INHBA) (N-Term), (AA 85-112) antibody

Details for Product No. ABIN655078
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Antigen
Epitope
N-Term, AA 85-112
(10), (8), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(35), (11), (6), (4), (4), (1), (1), (1)
Host
Rabbit
(47), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (5), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(49), (34), (23), (23), (14), (10), (8), (8), (1)
Pubmed 1 reference available
Quantity 400 µL
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Catalog No. ABIN655078
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Immunogen This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 AA from the N-terminal region of human INHBA.
Clone RB20703
Isotype Ig
Specificity This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-119 amino acids from the N-terminal region of human INHBA.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name INHBA
Background The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Synonyms: Inhibin beta A chain,INHBA,
Molecular Weight 47442 DA
Gene ID 3624
UniProt P08476, NP_002183.1
Research Area Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Inhibin, beta A (INHBA) (N-Term), (AA 85-112) antibody INHBA Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the INHBA antibody detected the INHBA protein (arrow).
anti-Inhibin, beta A (INHBA) (N-Term), (AA 85-112) antibody (2) INHBA Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of INHBA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Inhibin, beta A (INHBA) (N-Term), (AA 85-112) antibody (3) Confocal immunofluorescent analysis of INHBA Antibody (N-term) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
anti-Inhibin, beta A (INHBA) (N-Term), (AA 85-112) antibody (4) INHBA Antibody (N-term) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Canzian, Cox, Setiawan et al.: "Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3873-84, 2010 (PubMed).

Validation Images
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