INHBA antibody (N-Term)

Catalog No. ABIN952902

Product Details anti-INHBA Antibody

Target: INHBA (Inhibin, beta A (INHBA))

Binding Specificity: AA 92-119, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INHBA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to INHBA.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, BovineSpecies reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-119 amino acids from the N-terminal region of human INHBA.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -80 °C for longer.

Target Details for INHBA

Target: INHBA (Inhibin, beta A (INHBA))

Alternative Name: Inhibin beta A Chain (INHBA) (INHBA Products)

Background: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.Synonyms: Activin A, Activin BA, Activin beta-A chain, Erythroid differentiation protein

Molecular Weight: 47442 Da

Gene ID: 3624

NCBI Accession: NP_002183

Pathways: Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Autophagy