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Details for Product No. ABIN655398

Sp1 Transcription Factor (SP1) (C-Term), (AA 677-707) antibody

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Antigen
Synonyms Sp1-1, AA450830, AI845540, 1110003E12Rik, fc18h09, zgc:85950, wu:fc18h09, SP1
Epitope
»Alternatives C-Term, AA 677-707
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN655398
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 677-707 AA from the C-terminal region of human SP1.
Clone RB17350
Isotype Ig
Specificity This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 684-715 amino acids from the C-terminal region of human SP1.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SP1
Background Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Synonyms: SP1,Transcription factor Sp1,TSFP1
Molecular Weight 80693 DA
Gene ID 6667
UniProt NP_612482.2, NP_003100.1, P08047
Research Area Cell Structure, Signaling, Protein Modifications, Phospho-specific antibodies, Transcription Factors, Translation Factors, Ubiquitin-related antibodies
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,FC : 1:10-50,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Jutooru, Chadalapaka, Lei et al.: "Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25332-44, 2010 (PubMed).

Imanishi, Imamura, Higashi et al.: "Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Sp1." in: Biochemical and biophysical research communications, Vol. 400, Issue 4, pp. 625-30, 2010 (PubMed).

Pan, Yang, Wei et al.: "SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation." in: Biochemical and biophysical research communications, Vol. 401, Issue 2, pp. 306-12, 2010 (PubMed).

Mucha, Ooi, Linley et al.: "Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 40, pp. 13235-45, 2010 (PubMed).

Alternatives for antigen "Sp1 Transcription Factor (SP1)", type "Antibodies"
Hosts (104), (19), (6)
Reactivities (121), (75), (65), (14), (14), (13), (12), (2), (1)
Applications (103), (61), (31), (29), (25), (20), (11), (7), (5), (2), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (18), (14), (12), (11), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
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