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Details for Product No. ABIN655502

Pinin, Desmosome Associated Protein (PNN) (AA 209-239), (Center) antibody

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Antigen
Synonyms DRS, DRSP, SDK3, memA, wu:fb24d03, AU045199, D12Ertd512e, PNN, MGC127754, pnn, MGC88923, Pinin, DKFZp459I0427, CG8383, Dmel\\CG8383, dPnn
Epitope
»Alternatives AA 209-239, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN655502
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This PNN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-239 AA from the Central region of human PNN.
Clone RB17516
Isotype Ig
Specificity This PNN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-248 amino acids from the Central region of human PNN.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PNN
Background Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene, the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
Synonyms: Pinin,PNN,DRS, MEMA
Molecular Weight 81614 Da
Gene ID 5411
UniProt Q9H307
Research Area Cell Structure, Signaling, Protein Modifications, Cancer, Phospho-specific antibodies, Transcription Factors, Translation Factors
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Alpatov, Shi, Munguba et al.: "Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene." in: Molecular and cellular biology, Vol. 28, Issue 5, pp. 1584-95, 2008 (PubMed).

Alternatives for antigen "Pinin, Desmosome Associated Protein (PNN)", type "Antibodies"
Hosts (38), (4)
Reactivities (39), (25), (20), (14), (14), (13), (13), (1), (1)
Applications (33), (20), (10), (5), (5), (4), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (4), (3), (2), (2), (1), (1)
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