PNN antibody

Catalog No. ABIN7075083

The Rabbit Polyclonal anti-PNN antibody is suitable to detect PNN in samples from Human, Mouse and Rat. It has been validated for IHC and IF.

Quick Overview for PNN antibody (ABIN7075083)

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNN antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PNN Antibody

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse PNN/DRSP

Application Details

Application Notes: IHC/IF (H,M,R) 1:600-1:1200/1:400-1:800

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for PNN

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Alternative Name: PNN/DRSP

Background: PNN, also named as DRS or 140 kDa nuclear and cell adhesion-related phosphoprotein, is a 717 amino acid protein, which belongs to the pinin family. PNN localizes in the plasma membrane and is expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. PNN is expressed strongly in melanoma metastasis lesions and advanced primary tumors. PNN as a transcriptional activator binds to the E-box 1 core sequence of the E-cadherin promoter gene. PNN is involved in the establishment and maintenance of epithelia cell-cell adhesion. PNN is a potential tumor suppressor for renal cell carcinoma.

Gene ID: 18949

NCBI Accession: NP_032917

UniProt: O35691