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Integrin alpha-8 / ITGA8 (C-Term), (AA 1025-1053) antibody

Details for Product No. ABIN655529
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Antigen
Synonyms AI447669, RGD1564327
Epitope
C-Term, AA 1025-1053
(8), (8), (2), (2), (2), (1), (1)
Reactivity
Human
(16), (3)
Host
Rabbit
(12), (5), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(18), (10), (7), (5), (3), (2), (1)
Pubmed 4 references available
Quantity 400 µL
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN655529
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This ITGA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1025-1053 AA from the C-terminal region of human ITGA8.
Clone RB20555
Isotype Ig
Specificity This ITGA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1032-1061 amino acids from the C-terminal region of human ITGA8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ITGA8
Background Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Synonyms: Integrin alpha-8,ITGA8,
Molecular Weight 117474 DA
Gene ID 8516
UniProt P53708, NP_003629.1
Research Area Cell Structure, Neurology, Protein Modifications, Cell Cycle, Cell Signaling
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.29 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Integrin alpha-8 / ITGA8 (C-Term), (AA 1025-1053) antibody ITGA8 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ITGA8 antibody detected the ITGA8 protein (arrow).
anti-Integrin alpha-8 / ITGA8 (C-Term), (AA 1025-1053) antibody (2) ITGA8 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITGA8 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Sato, Uemura, Morimitsu et al.: "Molecular basis of the recognition of nephronectin by integrin alpha8beta1." in: The Journal of biological chemistry, Vol. 284, Issue 21, pp. 14524-36, 2009 (PubMed).

Benoit, Lussier, Ducharme et al.: "Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 101, Issue 12, pp. 695-708, 2009 (PubMed).

Simón-Sánchez, Schulte, Bras et al.: "Genome-wide association study reveals genetic risk underlying Parkinson's disease...." in: Nature genetics, Vol. 41, Issue 12, pp. 1308-12, 2009 (PubMed).

Benoit, Larrivée, Groulx et al.: "Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells." in: Biochemical and biophysical research communications, Vol. 399, Issue 3, pp. 434-9, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN655529
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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