Integrin alpha-8 / ITGA8 (C-Term), (AA 1025-1053) antibody

Details for Product No. ABIN655529
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Synonyms AI447669, RGD1564327
C-Term, AA 1025-1053
(2), (2), (2), (2), (2), (1), (1)
(10), (3)
(6), (5), (3)
Clonality (Clone)
Polyclonal ()
(1), (1), (1)
Western Blotting (WB), Immunohistochemistry (IHC)
(12), (5), (4), (3), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN655529
Quantity 400 µL
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Immunogen This ITGA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1025-1053 AA from the C-terminal region of human ITGA8.
Clone RB20555
Isotype Ig
Specificity This ITGA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1032-1061 amino acids from the C-terminal region of human ITGA8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ITGA8
Background Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Synonyms: Integrin alpha-8,ITGA8,
Molecular Weight 117474 DA
Gene ID 8516
UniProt P53708, NP_003629.1
Research Area Cell Structure, Neurology, Protein Modifications, Cell Cycle, Cell Signaling
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.29 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Integrin alpha-8 / ITGA8 (C-Term), (AA 1025-1053) antibody ITGA8 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ITGA8 antibody detected the ITGA8 protein (arrow).
anti-Integrin alpha-8 / ITGA8 (C-Term), (AA 1025-1053) antibody (2) ITGA8 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITGA8 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Sato, Uemura, Morimitsu et al.: "Molecular basis of the recognition of nephronectin by integrin alpha8beta1." in: The Journal of biological chemistry, Vol. 284, Issue 21, pp. 14524-36, 2009 (PubMed).

Benoit, Lussier, Ducharme et al.: "Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 101, Issue 12, pp. 695-708, 2009 (PubMed).

Simón-Sánchez, Schulte, Bras et al.: "Genome-wide association study reveals genetic risk underlying Parkinson's disease...." in: Nature genetics, Vol. 41, Issue 12, pp. 1308-12, 2009 (PubMed).

Benoit, Larrivée, Groulx et al.: "Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells." in: Biochemical and biophysical research communications, Vol. 399, Issue 3, pp. 434-9, 2010 (PubMed).

Hosts (6), (5), (3)
Reactivities (10), (3)
Applications (12), (5), (4), (3), (2), (1), (1)
Conjugates (1), (1), (1)
Epitopes (2), (2), (2), (2), (2), (1), (1)
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