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Betacellulin (BTC) (N-Term), (AA 17-45) antibody

Details for Product No. ABIN655615
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Antigen
Synonyms BTC, LOC100228121, probetacellulin, Bcn
Epitope
N-Term, AA 17-45
(6), (4), (3), (3), (2), (2), (1)
Reactivity
Human
(55), (7), (1)
Host
Rabbit
(53), (5), (1), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(8), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(45), (25), (18), (14), (11), (10), (5), (5), (5), (3), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN655615
291.50 $
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Immunogen This BTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 AA from the N-terminal region of human BTC.
Clone RB14431
Isotype Ig
Specificity This BTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-54 amino acids from the N-terminal region of human BTC.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name BTC
Background The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor.
Synonyms: RB14431
Pathways: ErbB signaling pathway
Molecular Weight 19746 Da
Gene ID 685
UniProt P35070
Research Area Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Betacellulin (BTC) (N-Term), (AA 17-45) antibody Confocal immunofluorescent analysis of BTC Antibody (N-term)(ABIN655615) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Background publications Moss, Bomar, Liu et al.: "The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events." in: The Journal of biological chemistry, Vol. 282, Issue 49, pp. 35712-21, 2007 (PubMed).

Révillion, Lhotellier, Hornez et al.: "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis." in: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 19, Issue 1, pp. 73-80, 2007 (PubMed).

Nagaoka, Fukuda, Hashizume et al.: "A betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with low affinity of binding to ErbB1." in: Journal of molecular biology, Vol. 380, Issue 1, pp. 83-94, 2008 (PubMed).

Genetos, Rao, Vidal: "Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alpha." in: Cell and tissue research, Vol. 340, Issue 1, pp. 81-9, 2010 (PubMed).

Stoeck, Shang, Dempsey: "Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth." in: Journal of cell science, Vol. 123, Issue Pt 13, pp. 2319-31, 2010 (PubMed).

Validation Images
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