Interferon Regulatory Factor 9 (IRF9) (N-Term), (AA 75-104) antibody

Details for Product No. ABIN655818
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Antigen
Synonyms IRF-9, ISGF3, ISGF3G, p48, zgc:92097, Irf-9, Isgf3g
Epitope
N-Term, AA 75-104
(10), (8), (8), (5), (2), (1), (1), (1)
Reactivity
Mouse (Murine)
(33), (13), (1), (1), (1), (1), (1)
Host
Rabbit
(26), (13), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(40), (24), (23), (12), (10), (8), (3), (2), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN655818
291.50 $
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Immunogen This IRF9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 AA from the N-terminal region of human IRF9.
Clone RB19229
Isotype Ig
Specificity This IRF9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-112 amino acids from the N-terminal region of human IRF9.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IRF9
Background IRF9 is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Synonyms: Interferon regulatory factor 9,IRF9,ISGF3G
Molecular Weight 43696 DA
Gene ID 10379
NCBI Accession NP_006075
UniProt Q00978
Research Area Translation Factors, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.28 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Interferon Regulatory Factor 9 (IRF9) (N-Term), (AA 75-104) antibody IRF9 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the IRF9 antibody detected the IRF9 protein (arrow).
anti-Interferon Regulatory Factor 9 (IRF9) (N-Term), (AA 75-104) antibody (2) IRF9 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IRF9 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Interferon Regulatory Factor 9 (IRF9) (N-Term), (AA 75-104) antibody (3) Confocal immunofluorescent analysis of IRF9 Antibody (N-term) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
Background publications Mosbruger, Duggal, Goedert et al.: "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus." in: The Journal of infectious diseases, Vol. 201, Issue 9, pp. 1371-80, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

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