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Details for Product No. ABIN655822

Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15) (AA 148-175), (Center) antibody

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Antigen
Synonyms TL1, TL1A, VEGI, VEGI192A, Tl1, Tl1a, Vegi, TTPAL
Epitope
»Alternatives AA 148-175, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
Pubmed 5 references available
Catalog no. ABIN655822
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This TNFSF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-175 AA from the Central region of human TNFSF15.
Clone RB21818
Isotype Ig
Specificity This TNFSF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human TNFSF15.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TNFSF15
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq].
Synonyms: Tumor necrosis factor ligand superfamily member 15,TNFSF15,TL1, VEGI
Molecular Weight 28087 DA
Gene ID 9966
UniProt O95150, NP_005109.2
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IF : 1:10-50,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Heidemann, Chavez, Landers et al.: "TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets." in: Journal of clinical immunology, Vol. 30, Issue 4, pp. 531-8, 2010 (PubMed).

Nakagome, Takeyama, Mano et al.: "Population-specific susceptibility to Crohn's disease and ulcerative colitis; dominant and recessive relative risks in the Japanese population." in: Annals of human genetics, Vol. 74, Issue 2, pp. 126-36, 2010 (PubMed).

McLaren, Calder, McSharry et al.: "The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 10, pp. 5827-34, 2010 (PubMed).

Amre, Mack, Morgan et al.: "Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children." in: Human genetics, Vol. 128, Issue 2, pp. 131-5, 2010 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15)", type "Antibodies"
Hosts (65), (7)
Reactivities (72), (32), (26), (17), (17), (17), (17)
Applications (53), (38), (20), (10), (9), (8), (3), (3), (2), (1), (1), (1), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (3), (2), (1), (1), (1), (1), (1)
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