RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1) (AA 217-244), (Center) antibody

Details for Product No. ABIN655886
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Antigen
Synonyms GDS1, SmgGDS, BC011279, XsmgGDS, gds1, rap1gds1, smgGDS
Epitope
AA 217-244, Center
(8), (7), (3), (2), (1), (1), (1)
Reactivity
Human
(30), (14), (12), (2)
Host
Rabbit
(29), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(21), (10), (10), (9), (7), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN655886
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Immunogen This RAP1GDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 AA from the Central region of human RAP1GDS1.
Clone RB31690
Isotype Ig
Specificity This RAP1GDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-252 amino acids from the Central region of human RAP1GDS1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RAP1GDS1
Background The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).
Synonyms: Rap1 GTPase-GDP dissociation stimulator 1,RAP1GDS1,
Molecular Weight 66317 DA
Gene ID 5910
NCBI Accession NP_001093900
UniProt P52306
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes IHC = 1:10-50, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1) (AA 217-244), (Center) antibody RAP1GDS1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RAP1GDS1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1) (AA 217-244), (Center) antibody (2) RAP1GDS1 Antibody (Center) western blot analysis in HepG2,MDA-MB231 cell line lysates (35ug/lane).This demonstrates the RAP1GDS1 antibody detected the RAP1GDS1 protein (arrow).
Background publications Tiwari, Felekkis, Moon et al.: "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis." in: Blood, Vol. 103, Issue 7, pp. 2661-7, 2004 (PubMed).

Branham, Bustos, De Blas et al.: "Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 24825-39, 2009 (PubMed).

Schönherr, Yang, Vigny et al.: "Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells." in: Oncogene, Vol. 29, Issue 19, pp. 2817-30, 2010 (PubMed).

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