Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) (AA 442-470), (Center) antibody

Details for Product No. ABIN656260
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Antigen
Synonyms Xdsh, dsh1, dvl-1, DVL, DVL1L1, DVL1P1, DSH, DVL-22, DVL1, DVL4, Dvl, mKIAA4029, DVL-1, dvl1, dvl2l
Epitope
AA 442-470, Center
(10), (7), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(34), (18), (16), (3), (3), (2), (1), (1), (1)
Host
Rabbit
(31), (4), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(29), (11), (10), (9), (6), (4), (3), (2), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN656260
291.50 $
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Immunogen This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 AA from the Central region of human DVL1.
Clone RB31716
Isotype Ig
Specificity This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from the Central region of human DVL1.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DVL1
Background DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Synonyms: DVL1,Segment polarity protein dishevelled homolog DVL-1,
Pathways: Wnt signaling pathway, Melanogenesis, Basal cell carcinoma
Molecular Weight 75187 Da
Gene ID 1855
UniProt O14640
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.46 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) (AA 442-470), (Center) antibody Confocal immunofluorescent analysis of DVL1 Antibody (Center) (ABIN656260) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Background publications Varelas, Miller, Sopko et al.: "The Hippo pathway regulates Wnt/beta-catenin signaling." in: Developmental cell, Vol. 18, Issue 4, pp. 579-91, 2010 (PubMed).

Validation Images
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