Immunoglobulin Superfamily, Member 8 (IGSF8) (AA 226-254), (Center) antibody

Details for Product No. ABIN656323
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Antigen
Epitope
AA 226-254, Center
(12), (8), (3), (2), (1), (1)
Reactivity
Mouse (Murine)
(40), (22), (20), (17), (17)
Host
Rabbit
(37), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(19), (15), (13), (10), (10), (6)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN656323
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Immunogen This IGSF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 AA from the Central region of human IGSF8.
Clone RB31348
Isotype Ig
Specificity This IGSF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233-262 amino acids from the Central region of human IGSF8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IGSF8
Background IGSF8 may play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Synonyms: IGSF8,Immunoglobulin superfamily member 8,CD81P3, EWI2, KCT4
Molecular Weight 65034 DA
Gene ID 93185
NCBI Accession NP_443100
UniProt Q969P0
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.39 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment IGSF8 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Immunoglobulin Superfamily, Member 8 (IGSF8) (AA 226-254), (Center) antibody IGSF8 Antibody (Center) (ABIN656323) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Yang, Kovalenko, Kolesnikova et al.: "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization." in: The Journal of biological chemistry, Vol. 281, Issue 18, pp. 12976-85, 2006 (PubMed).

Kolesnikova, Kazarov, Lemieux et al.: "Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 1, pp. 77-86, 4p following 86, 2008 (PubMed).

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