IGSF8 antibody (Middle Region)

Catalog No. ABIN2788247

Product Details anti-IGSF8 Antibody

Target: IGSF8 (Immunoglobulin Superfamily, Member 8 (IGSF8))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Cow, Pig, Rabbit, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGSF8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LAVEAGAPYA ERLAAGELRL GKEGTDRYRM VVGGAQAGDA GTYHCTAAEW

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 83%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%

Characteristics: This is a rabbit polyclonal antibody against IGSF8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IGSF8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 613 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IGSF8

Target: IGSF8 (Immunoglobulin Superfamily, Member 8 (IGSF8))

Alternative Name: IGSF8 (IGSF8 Products)

Synonyms: MGC77222 antibody, IGSF8 antibody, MGC151661 antibody, CD316 antibody, CD81P3 antibody, EWI-2 antibody, EWI2 antibody, KCT-4 antibody, LIR-D1 antibody, PGRL antibody, AA033172 antibody, AU041109 antibody, ESTM34 antibody, R75384 antibody, immunoglobulin superfamily, member 8 antibody, immunoglobulin superfamily member 8 antibody, igsf8 antibody, IGSF8 antibody, Igsf8 antibody

Background: IGSF8 may play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. IGSF8 may regulate proliferation and differentiation of keratinocytes. IGSF8 may be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. IGSF8 may also play a role on integrin-dependent morphology and motility functions. IGSF8 may participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Alias Symbols: CD316, CD81P3, EWI2, PGRL, EWI-2, KCT-4, LIR-D1
Protein Interaction Partner: KRTAP10-3, KRTAP10-8, KRTAP10-9, KRTAP10-7, KRTAP10-4, UBC, FBXO6, HIST1H2BK, TUBB6, TUBB7P, VPS35, TUBA8, EIF3L, TUBE1, RPL26L1, YBX2, EIF3K, LSM3, PDCD4, PABPC1, IBTK, RPL36, RPL13A, SF3B3, RPL35, SUPT16H, SRSF8, PRPF8, CCT4, ANP32B, DDX17, SYNCRIP, TUB
Protein Size: 613

Molecular Weight: 65 kDa

Gene ID: 93185

NCBI Accession: NM_052868, NP_443100

UniProt: Q969P0