IGSF8 antibody (Middle Region)

Catalog No. ABIN2788247

The Rabbit Polyclonal anti-IGSF8 antibody (ABIN2788247) specifically detects IGSF8 in WB. The antibody is reactive with Human, Mouse, Rabbit, Cow, Pig, Dog and Guinea Pig samples.

Quick Overview for IGSF8 antibody (Middle Region) (ABIN2788247)

Target: IGSF8 (Immunoglobulin Superfamily, Member 8 (IGSF8))

Reactivity: Human, Mouse, Rabbit, Cow, Pig, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGSF8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IGSF8 Antibody

Binding Specificity: Middle Region

Purpose: IGSF8 Antibody - middle region

Sequence: LAVEAGAPYA ERLAAGELRL GKEGTDRYRM VVGGAQAGDA GTYHCTAAEW

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 83%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%

Characteristics: This is a rabbit polyclonal antibody against IGSF8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IGSF8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59875-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for IGSF8

Target: IGSF8 (Immunoglobulin Superfamily, Member 8 (IGSF8))

Alternative Name: IGSF8

Background:

Background Information: IGSF8 may play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. IGSF8 may regulate proliferation and differentiation of keratinocytes. IGSF8 may be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. IGSF8 may also play a role on integrin-dependent morphology and motility functions. IGSF8 may participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

Gene Name: Immunoglobulin superfamily, member 8

Alternative Symbols: EWI2, PGRL, CD316, EWI-2, KCT-4, CD81P3, LIR-D1

Protein Name: Immunoglobulin superfamily member 8

Molecular Weight: 65kDa

Gene ID: 93185

NCBI Accession: NP_443100

UniProt: Q969P0