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Details for Product No. ABIN656914

La Ribonucleoprotein Domain Family, Member 7 (LARP7) (C-Term), (AA 527-556) antibody

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Antigen
Synonyms ALAZS, PIP7S, D3Wsu161e, C330027G06Rik, fa10g04, zgc:56476, wu:fa10g04, LARP7
Epitope
»Alternatives C-Term, AA 527-556
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN656914
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This LARP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 AA from the C-terminal region of human LARP7.
Clone RB32547
Isotype Ig
Specificity This LARP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 526-556 amino acids from the C-terminal region of human LARP7.
Predicted Reactivity Mouse (Murine),Monkey,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name LARP7
Background LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Synonyms: La-related protein 7,LARP7,
Molecular Weight 66899 DA
Gene ID 51574
UniProt NP_056269.1, NP_057732.2, Q4G0J3
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.44 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment LARP7 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications He, Jahchan, Hong et al.: "A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis." in: Molecular cell, Vol. 29, Issue 5, pp. 588-99, 2008 (PubMed).

Kalsi, Kuo, Aliev et al.: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." in: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, 2010 (PubMed).

Tyagi, Pearson, Karn: "Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction." in: Journal of virology, Vol. 84, Issue 13, pp. 6425-37, 2010 (PubMed).

Alternatives for antigen "La Ribonucleoprotein Domain Family, Member 7 (LARP7)", type "Antibodies"
Hosts (15)
Reactivities (10), (5), (4), (2), (2), (2), (1)
Applications (12), (5), (2)
Conjugates (1), (1)
Epitopes (7), (2), (1), (1), (1)
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