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N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1) (AA 820-849), (C-Term) antibody

Details for Product No. ABIN657148, Supplier: Login to see
Antigen
  • fj47c03
  • ndst1
  • wu:fj47c03
  • NDST1
  • HSST
  • NST1
  • 1200015G06Rik
  • Hsst
  • NDST-1
Epitope
AA 820-849, C-Term
16
15
4
4
4
1
1
Reactivity
Human
46
3
3
Host
Rabbit
37
9
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
30
23
20
11
7
Supplier
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Immunogen This NDST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 820-849 AA from the C-terminal region of human NDST1.
Clone RB33030
Isotype Ig
Specificity This NDST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 819-849 amino acids from the C-terminal region of human NDST1.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NDST1 (NDST1 Antibody Abstract)
Background NDST1 is an essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.
Synonyms: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1,NDST1,HSST, HSST1
Research Area Cell Signaling, Protein Modifications, Cell Structure, Metabolism
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunohistochemistry (IHC) image for anti-N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1) (AA 820-849), (C-Term) antibody (ABIN657148) NDST1 Antibody (C-term) (ABIN657148) immunohistochemistry analysis in formalin fixed ...
Background publications Zuberi, Ge, Jiang et al.: "Deficiency of endothelial heparan sulfates attenuates allergic airway inflammation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 6, pp. 3971-9, 2009 (PubMed).

Drenos, Talmud, Casas et al.: "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk." in: Human molecular genetics, Vol. 18, Issue 12, pp. 2305-16, 2009 (PubMed).