NDST1 antibody (AA 40-556)

Catalog No. ABIN7145570

This Rabbit Polyclonal antibody specifically detects NDST1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for NDST1 antibody (AA 40-556) (ABIN7145570)

Target: NDST1 (N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NDST1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-NDST1 Antibody

Binding Specificity: AA 40-556

Purpose: NDST1 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 protein (40-556AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NDST1

Target: NDST1 (N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1))

Alternative Name: NDST1

Background:

Background: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.

Aliases: NDST1 antibody, HSST antibody, HSST1 antibody, Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 antibody, EC 2.8.2.8 antibody, Glucosaminyl N-deacetylase/N-sulfotransferase 1 antibody, NDST-1 antibody, N-heparan sulfate sulfotransferase 1 antibody, N-HSST 1 antibody, [Heparan sulfate]-glucosamine N-sulfotransferase 1 antibody, HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 antibody, EC 3.-.-.-), Heparan sulfate N-sulfotransferase 1 antibody, EC 2.8.2.-)] antibody

UniProt: P52848

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Glycosaminoglycan Metabolic Process