Ral Guanine Nucleotide Dissociation Stimulator-Like 2 (RGL2) (N-Term), (AA 152-180) antibody

Details for Product No. ABIN657382
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Antigen
Epitope
N-Term, AA 152-180
(9), (7), (6), (1)
Reactivity
Human
(18)
Host
Rabbit
(10), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(18), (15), (7), (3)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN657382
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Immunogen This RGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 AA from the N-terminal region of human RGL2.
Clone RB33009
Isotype Ig
Specificity This RGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human RGL2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RGL2
Background Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).
Synonyms: Ral guanine nucleotide dissociation stimulator-like 2,RGL2,RAB2L
Molecular Weight 83549 DA
Gene ID 5863
NCBI Accession NP_004752
UniProt O15211
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.44 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment RGL2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Ral Guanine Nucleotide Dissociation Stimulator-Like 2 (RGL2) (N-Term), (AA 152-180) antibody RGL2 Antibody (N-term) (ABIN657382) western blot analysis in uterine tumor cell line lysates (35 µg/lane). This demonstrates the RGL2 antibody detected the RGL2 protein (arrow).
Background publications Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome...." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).

Wu, Ma, Brown et al.: "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening." in: Proteomics, Vol. 7, Issue 11, pp. 1775-85, 2007 (PubMed).

Ferro, Magrini, Guazzi et al.: "G-protein binding features and regulation of the RalGDS family member, RGL2." in: The Biochemical journal, Vol. 415, Issue 1, pp. 145-54, 2008 (PubMed).

Barcellos, May, Ramsay et al.: "High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions." in: PLoS genetics, Vol. 5, Issue 10, pp. e1000696, 2009 (PubMed).

Vigil, Martin, Williams et al.: "Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34729-40, 2010 (PubMed).

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