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Details for Product No. ABIN657457

Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (C-Term), (AA 226-254) antibody

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Antigen
Synonyms CD16, FCG3, CD16A, FCGR3, IGFR3, FCR-10, FCRIII, FCGRIII, FCRIIIA
Epitope
»Alternatives C-Term, AA 226-254
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN657457
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This FCGR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 AA from the C-terminal region of human FCGR3A.
Clone RB33601
Isotype Ig
Specificity This FCGR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-254 amino acids from the C-terminal region of human FCGR3A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FCGR3A
Background This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: Low affinity immunoglobulin gamma Fc region receptor III-A,FCGR3A,CD16A, FCG3, FCGR3, IGFR3
Molecular Weight 29089 DA
Gene ID 2214
UniProt P08637, NP_001121067.1, NP_001121064.1, NP_000560.5, NP_001121068.1, NP_001121065.1
Research Area Cell Signaling, Cell Structure, Protein Modifications
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment FCGR3A Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Dornan, Spleiss, Yeh et al.: "Effect of FCGR2A and FCGR3A variants on CLL outcome." in: Blood, Vol. 116, Issue 20, pp. 4212-22, 2010 (PubMed).

Li, Chen, Evens et al.: "Rituximab-induced late-onset neutropenia in newly diagnosed B-cell lymphoma correlates with Fc receptor FcγRIIIa 158(V/F) polymorphism." in: American journal of hematology, Vol. 85, Issue 10, pp. 810-2, 2010 (PubMed).

Alternatives for antigen "Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A)", type "Antibodies"
Hosts (55), (33)
Reactivities (86), (19), (17), (17), (17), (1), (1), (1), (1), (1)
Applications (53), (30), (14), (14), (11), (10), (10), (8), (6), (2), (1), (1)
Conjugates (9), (7), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (1), (1), (1), (1), (1)
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