Mucolipin 1 (MCOLN1) (C-Term), (AA 531-560) antibody

Details for Product No. ABIN657474
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Antigen
Epitope
C-Term, AA 531-560
(21), (12), (7), (5), (1), (1), (1), (1), (1)
Reactivity
Human
(32), (10), (9), (4), (1)
Host
Rabbit
(29), (2), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(33), (18), (9), (3), (2), (1)
Pubmed 3 references available
Quantity 400 μL
Options
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Immunogen This MCOLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 AA from the C-terminal region of human MCOLN1.
Clone RB33839
Isotype Ig
Specificity This MCOLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 530-560 amino acids from the C-terminal region of human MCOLN1.
Predicted Reactivity Mouse (Murine),Monkey
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MCOLN1 (MCOLN1 Antibody Abstract)
Background This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.
Synonyms: Mucolipin-1,MCOLN1,ML4
Molecular Weight 65022 DA
Gene ID 57192
NCBI Accession NP_065394
UniProt Q9GZU1
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.31 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MCOLN1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Mucolipin 1 (MCOLN1) (C-Term), (AA 531-560) antibody MCOLN1 Antibody (C-term) (ABIN657474) western blot analysis in Jurkat cell line lysat...
Background publications Eichelsdoerfer, Evans, Slaugenhaupt et al.: "Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34304-8, 2010 (PubMed).

Curcio-Morelli, Zhang, Venugopal et al.: "Functional multimerization of mucolipin channel proteins." in: Journal of cellular physiology, Vol. 222, Issue 2, pp. 328-35, 2009 (PubMed).

Vergarajauregui, Martina, Puertollano: "Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1." in: The Journal of biological chemistry, Vol. 284, Issue 52, pp. 36357-66, 2009 (PubMed).

Validation Images
Catalog No. ABIN657474
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