Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN657474

Mucolipin 1 (MCOLN1) (C-Term), (AA 531-560) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms MG-2, ML4, MLIV, MST080, TRP-ML1, TRPM-L1, TRPML1, 2210015I05Rik, mucolipidin, mcoln1, mcoln1.1, zgc:63619, mln1, mucolipin-1, MCOLN1
Epitope
»Alternatives C-Term, AA 531-560
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN657474
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen This MCOLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 AA from the C-terminal region of human MCOLN1.
Clone RB33839
Isotype Ig
Specificity This MCOLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 530-560 amino acids from the C-terminal region of human MCOLN1.
Predicted Reactivity Mouse (Murine),Monkey
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MCOLN1
Background This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.
Synonyms: Mucolipin-1,MCOLN1,ML4
Molecular Weight 65022 DA
Gene ID 57192
UniProt NP_065394.1, Q9GZU1
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.31 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment MCOLN1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Vergarajauregui, Martina, Puertollano: "Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1." in: The Journal of biological chemistry, Vol. 284, Issue 52, pp. 36357-66, 2009 (PubMed).

Curcio-Morelli, Zhang, Venugopal et al.: "Functional multimerization of mucolipin channel proteins." in: Journal of cellular physiology, Vol. 222, Issue 2, pp. 328-35, 2009 (PubMed).

Eichelsdoerfer, Evans, Slaugenhaupt et al.: "Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34304-8, 2010 (PubMed).

Alternatives for antigen "Mucolipin 1 (MCOLN1)", type "Antibodies"
Hosts (19), (1), (1), (1)
Reactivities (20), (10), (10), (1), (1)
Applications (22), (4), (3), (1), (1), (1)
Conjugates (2), (2), (2), (1), (1)
Epitopes (11), (7), (2), (1), (1), (1)
Beacon