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Keratin 6B (KRT6B) (AA 207-236), (Center) antibody

Details for Product No. ABIN657654
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Antigen
Epitope
AA 207-236, Center
(7), (6), (1)
Reactivity
Human
(19), (3), (3)
Host
Rabbit
(12), (7)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(19), (14), (10), (1), (1)
Pubmed 1 reference available
Quantity 400 µL
Options
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Catalog No. ABIN657654
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Immunogen This KRT6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-236 AA from the Central region of human KRT6B.
Clone RB33708
Isotype Ig
Specificity This KRT6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the Central region of human KRT6B.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KRT6B
Background The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified, the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq].
Synonyms: Keratin, type II cytoskeletal 6B,KRT6B,K6B, KRTL1
Molecular Weight 60067 DA
Gene ID 3854
UniProt P04259, NP_005546.2
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment KRT6B Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Keratin 6B (KRT6B) (AA 207-236), (Center) antibody KRT6B Antibody (Center) (ABIN657654) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the KRT6B antibody detected the KRT6B protein (arrow).
Background publications Takahashi, Paladini, Coulombe: "Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms." in: The Journal of biological chemistry, Vol. 270, Issue 31, pp. 18581-92, 1995 (PubMed).

Validation Images
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