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Keratin 6B antibody

KRT6B Reactivity: Human IHC (f) Host: Mouse Monoclonal unconjugated
Catalog No. ABIN7126618
  • Target See all Keratin 6B (KRT6B) Antibodies
    Keratin 6B (KRT6B)
    Reactivity
    • 27
    • 3
    • 1
    Human
    Host
    • 25
    • 2
    Mouse
    Clonality
    • 26
    • 1
    Monoclonal
    Conjugate
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Keratin 6B antibody is un-conjugated
    Application
    • 19
    • 16
    • 14
    • 3
    • 2
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    This MAb recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
    Cross-Reactivity (Details)
    Human and Mouse.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length human KRT6B protein
    Isotype
    IgG2a
    Top Product
    Discover our top product KRT6B Primary Antibody
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Positive_Control: Tonsil or basal cell carcinoma

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    Keratin 6B (KRT6B)
    Alternative Name
    KRT6B (KRT6B Products)
    Synonyms
    CK-6B antibody, CK6B antibody, K6B antibody, KRTL1 antibody, PC2 antibody, KRT6C antibody, KRT6A antibody, KRT6B antibody, BB144589 antibody, Krt2-6b antibody, mK6[b] antibody, KERIV antibody, keratin 6B antibody, keratin, type II cytoskeletal 5 antibody, keratin, type II cytoskeletal 6B antibody, KRT6B antibody, Krt6b antibody, LOC100566088 antibody, LOC100593588 antibody
    Background
    CK6B, Keratin Type II Cytoskeletal 6B, KRT6B,Cytokeratin 6B (KRT6B) (Basal Cell Marker)
    Cellular localisation: Cytoplasmic
    Molecular Weight
    56kDa
    Gene ID
    3854, 700779
    UniProt
    P04259
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