Mitochondrial Antiviral Signaling Protein (MAVS) (C-Term), (AA 477-505) antibody

Details for Product No. ABIN657705
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Antigen
Synonyms VISA, HISPPD2A, IP6K, IPS1, VIP1, hsVIP1, CARDIF, IPS-1, D430028G21Rik, Visa, cardif
Epitope
C-Term, AA 477-505
(23), (11), (9), (7), (5), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(70), (43), (33), (13)
Host
Rabbit
(77), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(68), (31), (20), (19), (10), (8), (4), (4), (1)
Pubmed 4 references available
Quantity 400 μL
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Catalog No. ABIN657705
291.50 $
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Immunogen This MAVS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-505 AA from the C-terminal region of human MAVS.
Clone RB33921
Isotype Ig
Specificity This MAVS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-505 amino acids from the C-terminal region of human MAVS.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MAVS
Background Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3, MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK, MIM 600664) and IKKB (IKBKB, MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE, MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1, MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1, MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).
Synonyms: Mitochondrial antiviral-signaling protein,MAVS,IPS1, KIAA1271, VISA
Molecular Weight 56528 DA
Gene ID 57506
NCBI Accession NP_065797
UniProt Q7Z434
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MAVS Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (C-Term), (AA 477-505) antibody MAVS Antibody (C-term) (ABIN657705) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the MAVS antibody detected the MAVS protein (arrow).
Background publications Graef, Vreede, Lau et al.: "The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon." in: Journal of virology, Vol. 84, Issue 17, pp. 8433-45, 2010 (PubMed).

Wei, Ni, Song et al.: "The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 2, pp. 1158-68, 2010 (PubMed).

Wang, Li, Mao et al.: "Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex." in: Cellular & molecular immunology, Vol. 7, Issue 5, pp. 341-8, 2010 (PubMed).

Rojas, Li, Zhang et al.: "The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo." in: The Journal of pharmacology and experimental therapeutics, Vol. 335, Issue 2, pp. 362-8, 2010 (PubMed).

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