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Details for Product No. ABIN657706

Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 177-206), (Center) antibody

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Antigen
Synonyms CD305, LAIR-1, Lair-1, mLair-1, BB115266, D7Bwg0421e, 5133400O11Rik
Epitope
»Alternatives AA 177-206, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN657706
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This LAIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 AA from the Central region of human LAIR1.
Clone RB33925
Isotype Ig
Specificity This LAIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-206 amino acids from the Central region of human LAIR1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name LAIR1
Background The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
Synonyms: Leukocyte-associated immunoglobulin-like receptor 1,LAIR1,CD305
Molecular Weight 31412 DA
Gene ID 3903
UniProt NP_002278.1, Q6GTX8, NP_068352.1
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment LAIR1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Tang, Narayanan, Peruzzi et al.: "A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5446-52, 2009 (PubMed).

Brondijk, de Ruiter, Ballering et al.: "Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI." in: Blood, Vol. 115, Issue 7, pp. 1364-73, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Alternatives for antigen "Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1)", type "Antibodies"
Hosts (64), (19), (10), (4), (1)
Reactivities (79), (23), (12)
Applications (64), (56), (25), (23), (10), (9), (6), (4)
Conjugates (11), (7), (7), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (5), (2), (2), (2), (1), (1), (1), (1), (1)
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