GDP Dissociation Inhibitor 2 (GDI2) (AA 135-164), (Center) antibody

Details for Product No. ABIN657709
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Antigen
Synonyms GDI-2, GDIB, Gdi3, GDI-B, RABGDIB, fc09e02, zgc:55919, zgc:77120, wu:fc09e02, GDI2
Epitope
AA 135-164, Center
(2), (1), (1), (1)
Reactivity
Human
(19), (3), (3), (1), (1), (1), (1), (1)
Host
Rabbit
(18), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(19), (10), (5), (3)
Pubmed 5 references available
Catalog no. ABIN657709
Quantity 400 µL
Price
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Immunogen This GDI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 AA from the Central region of human GDI2.
Clone RB33933
Isotype Ig
Specificity This GDI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human GDI2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name GDI2
Background GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: Rab GDP dissociation inhibitor beta,GDI2,RABGDIB
Molecular Weight 50663 DA
Gene ID 2665
UniProt NP_001485.2, P50395, NP_001108628.1
Research Area Signaling, Phospho-specific antibodies, Cell Structure, Protein Modifications
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment GDI2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-GDP Dissociation Inhibitor 2 (GDI2) (AA 135-164), (Center) antibody GDI2 Antibody (Center) (ABIN657709) western blot analysis in MCF-7 cell line lysates (35 µg/lane). This demonstrates the GDI2 antibody detected the GDI2 protein (arrow).
Background publications Shin, Wang, Yim et al.: "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7607-16, 2003 (PubMed).

Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Sun, Zhu, Wang et al.: "Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers." in: Biochimica et biophysica acta, Vol. 1774, Issue 6, pp. 764-71, 2007 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Hosts (18), (1)
Reactivities (19), (3), (3), (1), (1), (1), (1), (1)
Applications (19), (10), (5), (3)
Conjugates (2), (2), (2)
Epitopes (2), (1), (1), (1)
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