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Details for Product No. ABIN657943

Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term), (AA 79-108) antibody

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Antigen
Synonyms H3-K9-HMTase 1, KMT1A, MG44, SUV39H, mIS6, AI852103, AL022883, DXHXS7466e, RGD1565028, fe02c04, suv39h1, wu:fe02c04, zgc:101027, kmt1a, suv39h
Epitope
»Alternatives N-Term, AA 79-108
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN657943
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This SUV39H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 AA from the N-terminal region of human SUV39H1.
Clone RB34028
Isotype Ig
Specificity This SUV39H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from the N-terminal region of human SUV39H1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SUV39H1
Background This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
Synonyms: Histone-lysine N-methyltransferase SUV39H1,6839,KMT1A, SUV39H
Molecular Weight 47907 DA
Gene ID 6839
UniProt O43463, NP_003164.1
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment SUV39H1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Spensberger, Delwel: "A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a." in: FEBS letters, Vol. 582, Issue 18, pp. 2761-7, 2008 (PubMed).

Li, Chen, Kabra et al.: "Inhibition of SUV39H1 methyltransferase activity by DBC1." in: The Journal of biological chemistry, Vol. 284, Issue 16, pp. 10361-6, 2009 (PubMed).

Cherrier, Suzanne, Redel et al.: "p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1." in: Oncogene, Vol. 28, Issue 38, pp. 3380-9, 2009 (PubMed).

Goyama, Nitta, Yoshino et al.: "EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 24, Issue 1, pp. 81-8, 2010 (PubMed).

Chen, Li, Zwolinska et al.: "MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output." in: The EMBO journal, Vol. 29, Issue 15, pp. 2538-52, 2010 (PubMed).

Alternatives for antigen "Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1)", type "Antibodies"
Hosts (32), (10)
Reactivities (41), (26), (16), (14), (14), (12), (1), (1)
Applications (32), (14), (10), (6), (6), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (2), (1), (1), (1), (1), (1)
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