Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term), (AA 79-108) antibody

Details for Product No. ABIN657943
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Antigen
Epitope
N-Term, AA 79-108
(30), (7), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(60), (23), (16), (14), (14), (12), (1), (1)
Host
Rabbit
(46), (15)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(50), (28), (10), (10), (7), (6), (4), (2), (1)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN657943
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Immunogen This SUV39H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 AA from the N-terminal region of human SUV39H1.
Clone RB34028
Isotype Ig
Specificity This SUV39H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from the N-terminal region of human SUV39H1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SUV39H1
Background This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
Synonyms: Histone-lysine N-methyltransferase SUV39H1,6839,KMT1A, SUV39H
Molecular Weight 47907 DA
Gene ID 6839
NCBI Accession NP_003164
UniProt O43463
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SUV39H1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) (N-Term), (AA 79-108) antibody SUV39H1 Antibody (N-term) (ABIN657943) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the SUV39H1 antibody detected the SUV39H1 protein (arrow).
Background publications Spensberger, Delwel: "A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a." in: FEBS letters, Vol. 582, Issue 18, pp. 2761-7, 2008 (PubMed).

Li, Chen, Kabra et al.: "Inhibition of SUV39H1 methyltransferase activity by DBC1." in: The Journal of biological chemistry, Vol. 284, Issue 16, pp. 10361-6, 2009 (PubMed).

Cherrier, Suzanne, Redel et al.: "p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1." in: Oncogene, Vol. 28, Issue 38, pp. 3380-9, 2009 (PubMed).

Goyama, Nitta, Yoshino et al.: "EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization." in: Leukemia, Vol. 24, Issue 1, pp. 81-8, 2010 (PubMed).

Chen, Li, Zwolinska et al.: "MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output." in: The EMBO journal, Vol. 29, Issue 15, pp. 2538-52, 2010 (PubMed).

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