Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog, Drosophila) (MLL5) (N-Term), (AA 93-120) antibody

Details for Product No. ABIN658094
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Antigen
Epitope
N-Term, AA 93-120
(11), (7), (2)
Reactivity
Human
(27), (18), (13), (12), (12), (12)
Host
Rabbit
(31), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(19), (14), (10), (6), (5), (2), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN658094
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Immunogen This MLL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 AA from the N-terminal region of human MLL5.
Clone RB19215
Isotype Ig
Specificity This MLL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-121 amino acids from the N-terminal region of human MLL5.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MLL5
Background This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq].
Synonyms: Histone-lysine N-methyltransferase MLL5,MLL5,KMT2E
Molecular Weight 70kd Isoform 3. 204965 DA
Gene ID 55904
NCBI Accession NP_061152, NP_891847
UniProt Q8NFF8
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MLL5 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog, Drosophila) (MLL5) (N-Term), (AA 93-120) antibody MLL5 Antibody (N-term) (ABIN658094) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the MLL5 antibody detected the MLL5 protein (arrow).
Background publications Cheng, Liu, Zhou et al.: "RNA interference against mixed lineage leukemia 5 resulted in cell cycle arrest." in: The international journal of biochemistry & cell biology, Vol. 40, Issue 11, pp. 2472-81, 2008 (PubMed).

Fujiki, Chikanishi, Hashiba et al.: "GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis." in: Nature, Vol. 459, Issue 7245, pp. 455-9, 2009 (PubMed).

Liu, Wang, Cheng et al.: "Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry." in: The Journal of biological chemistry, Vol. 285, Issue 27, pp. 20904-14, 2010 (PubMed).

Validation Images
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