MLL5/KMT2E antibody (AA 182-316)

Catalog No. ABIN7155466

Product Details anti-MLL5/KMT2E Antibody

Target: MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))

Binding Specificity: AA 182-316

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL5/KMT2E antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MLL5/KMT2E

Target: MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))

Alternative Name: KMT2E (MLL5 Products)

Synonyms: HDCMC04P antibody, MLL5 antibody, 1810033J14Rik antibody, 9530077A04Rik antibody, D230038D11Rik antibody, Mll5 antibody, lysine methyltransferase 2E antibody, lysine (K)-specific methyltransferase 2E antibody, KMT2E antibody, Kmt2e antibody

Background:

Background: Histone methyltransferase that specifically mono- and dimethylates \'Lys-4\' of histone H3 (H3K4me1 and H3K4me2). H3 \'Lys-4\' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.

Aliases: HDCMC04P antibody, Histone lysine N methyltransferase MLL5 antibody, Histone-lysine N-methyltransferase MLL5 antibody, KMT2E antibody, Lysine N methyltransferase 2E antibody, Lysine N-methyltransferase 2E antibody, MGC70452 antibody, Mll5 antibody, MLL5_HUMAN antibody, Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog, Drosophila) antibody, Myeloid/lymphoid or mixed lineage leukemia 5 antibody, Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody, Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody

UniProt: Q8IZD2

Pathways: Retinoic Acid Receptor Signaling Pathway, Warburg Effect