Ret Proto-Oncogene (RET) antibody

Details for Product No. ABIN659065
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms c-ret, cret, etID315074.13, ret1, wu:fd13h01, X-ret, ret-A, xret, RET, MTC1, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, PTC, RET-ELE1, RET51, RET9, c-Ret
Reactivity
Human
(218), (95), (87), (48), (36), (24), (12), (12), (2), (2), (1)
Host
Mouse
(156), (62), (4), (1), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (9), (9), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(155), (103), (50), (46), (43), (28), (13), (7), (4), (2), (2), (2)
Pubmed 3 references available
Quantity 0.1 mL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN659065
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
Clone 188CT11-2-3
Isotype IgM, kappa
Specificity This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
Purification Ascites
Alternative Name RET
Background This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Synonyms: Proto-oncogene tyrosine-protein kinase receptor Ret,RET,CDHF12
Pathways: Pathways in cancer, Endocytosis, Thyroid cancer
Molecular Weight 124319 Da
Gene ID 5979
UniProt P07949
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cancer, Chromatin, Signaling, Neurology
Application Notes WB = 1:500-16000, IHC = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Ret Proto-Oncogene (RET) antibody Confocal immunofluorescent analysis of RET Antibody (Ascites) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green).Actin filaments have been labeled with Alexa Fluor? 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
anti-Ret Proto-Oncogene (RET) antibody (2) RET western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RET antibody detected the RET protein (arrow).
anti-Ret Proto-Oncogene (RET) antibody (3) RET Monoclonal( Ascites) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RET Monoclonal( Ascites) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Gockel, Schumacher, Gockel et al.: "Achalasia: will genetic studies provide insights?" in: Human genetics, Vol. 128, Issue 4, pp. 353-64, 2010 (PubMed).

Siqueira, Romitti, da Rocha et al.: "The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma." in: Endocrine-related cancer, Vol. 17, Issue 4, pp. 953-63, 2010 (PubMed).

Kim, Jung, Lim et al.: "A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population." in: Anticancer research, Vol. 30, Issue 9, pp. 3621-7, 2010 (PubMed).

Validation Images
Did you look for something else?
back to top