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Ret Proto-Oncogene antibody (RET)

Details for Product anti-RET Antibody No. ABIN659065, Supplier: Log in to see
Antigen
  • c-ret
  • cret
  • etID315074.13
  • ret1
  • wu:fd13h01
  • X-ret
  • ret-A
  • xret
  • RET
  • MTC1
  • CDHF12
  • CDHR16
  • HSCR1
  • MEN2A
  • MEN2B
  • PTC
  • RET-ELE1
  • RET51
  • RET9
  • c-Ret
Alternatives
anti-Human Ret Proto-Oncogene antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
322
100
91
12
5
3
1
Host
Mouse
230
91
5
1
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Ret Proto-Oncogene antibody is un-conjugated
15
14
13
10
9
7
6
5
5
5
5
5
5
5
5
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
223
135
79
55
55
22
19
8
5
5
3
3
1
1
Supplier
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Immunogen This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
Clone 188CT11-2-3
Isotype IgM, kappa
Specificity This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
Purification Ascites
Alternative Name RET (RET Antibody Abstract)
Background This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Synonyms: Proto-oncogene tyrosine-protein kinase receptor Ret,RET,CDHF12
Pathways: Pathways in cancer, Endocytosis, Thyroid cancer
Molecular Weight 124319 Da
Gene ID 5979
UniProt P07949
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cancer, Chromatin, Signaling, Neurology
Pathways RTK Signaling
Application Notes WB = 1:500-16000, IHC (p) = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ret Proto-Oncogene antibody (RET) (ABIN659065) RET western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates th...
Immunohistochemistry (IHC) image for anti-Ret Proto-Oncogene antibody (RET) (ABIN659065) RET Monoclonal( Ascites) immunohistochemistry analysis in formalin fixed and paraffi...
Immunofluorescence (IF) image for anti-Ret Proto-Oncogene antibody (RET) (ABIN659065) Confocal immunofluorescent analysis of RET Antibody (Ascites) with MDA-MB231 cell fol...
Background publications Kim, Jung, Lim et al.: "A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population." in: Anticancer research, Vol. 30, Issue 9, pp. 3621-7, 2010 (PubMed).

Siqueira, Romitti, da Rocha et al.: "The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma." in: Endocrine-related cancer, Vol. 17, Issue 4, pp. 953-63, 2010 (PubMed).

Gockel, Schumacher, Gockel et al.: "Achalasia: will genetic studies provide insights?" in: Human genetics, Vol. 128, Issue 4, pp. 353-64, 2010 (PubMed).