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Details for Product No. ABIN659065

Ret Proto-Oncogene (RET) antibody

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Synonyms CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51, RET9, c-Ret, c-ret, cret, etID315074.13, ret1, wu:fd13h01, X-ret, ret-A, xret, RET
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN659065
Quantity 0.1 mL
291.50 $   Plus shipping costs $45.00
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Immunogen This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
Clone 188CT11-2-3
Isotype IgM, kappa
Specificity This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
Purification Ascites
Alternative Name RET
Background This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Synonyms: Proto-oncogene tyrosine-protein kinase receptor Ret,RET,CDHF12
Pathways: Pathways in cancer, Endocytosis, Thyroid cancer
Molecular Weight 124319 Da
Gene ID 5979
UniProt P07949
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cancer, Chromatin, Signaling, Neurology
Application Notes Recommend dilutions: WB : 1:500-16000,IHC : 1:50-100,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Gockel, Schumacher, Gockel et al.: "Achalasia: will genetic studies provide insights?" in: Human genetics, Vol. 128, Issue 4, pp. 353-64, 2010 (PubMed).

Siqueira, Romitti, da Rocha et al.: "The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma." in: Endocrine-related cancer, Vol. 17, Issue 4, pp. 953-63, 2010 (PubMed).

Kim, Jung, Lim et al.: "A study of RET proto-oncogene polymorphisms in association with lung cancer risk in the Korean population." in: Anticancer research, Vol. 30, Issue 9, pp. 3621-7, 2010 (PubMed).

Alternatives for antigen "Ret Proto-Oncogene (RET)", type "Antibodies"
Hosts (116), (61), (4), (2), (1)
Reactivities (178), (91), (82), (48), (36), (24), (12), (12), (2), (2), (2), (1), (1), (1)
Applications (113), (88), (50), (40), (22), (11), (10), (5), (2), (2), (2), (1), (1)
Conjugates (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2), (2), (1)
Epitopes (31), (28), (16), (11), (9), (5), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)