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CD44 antibody (CD44)

Details for Product anti-CD44 Antibody No. ABIN659120, Supplier: Login to see
Antigen
  • AU023126
  • AW121933
  • AW146109
  • HERMES
  • Ly-24
  • Pgp-1
  • CD44A
  • METAA
  • RHAMM
  • CDW44
  • CSPG8
  • ECMR-III
  • HCELL
  • HUTCH-I
  • IN
  • LHR
  • MC56
  • MDU2
  • MDU3
  • MIC4
  • Pgp1
Reactivity
Human
848
348
143
44
30
28
26
23
15
12
11
7
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3
3
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1
1
1
1
1
Host
Mouse
718
243
185
17
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CD44 antibody is un-conjugated
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96
84
42
10
9
9
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4
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4
4
4
4
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2
1
1
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1
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1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
748
406
244
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174
147
121
54
47
21
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18
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16
8
7
7
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6
5
5
5
5
4
1
1
Supplier
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Immunogen This CD44 monoclonal antibody is generated from mouse immunized with CD44 recombinant protein.
Clone Hermes-3
Isotype IgG2a, kappa
Specificity This CD44 monoclonal antibody is generated from mouse immunized with CD44 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name CD44 (CD44 Antibody Abstract)
Background The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Synonyms: LHR, MDU2, MDU3, MIC4,CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD_antigen=CD44, Flags: Precursor
Pathways: Hematopoietic cell lineage, ECM-receptor interaction, Shigellosis
Molecular Weight 81,538 Da
Gene ID 960
UniProt P16070
Research Area Cell Structure
Pathways
Application Notes WB = 1:100-500, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CD44 antibody (CD44) (ABIN659120) CD44 antibody western blot analysis in Hela cell line lysates (35ug/lane).This demon...
Immunohistochemistry (IHC) image for anti-CD44 antibody (CD44) (ABIN659120) CD44 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded ...
Immunofluorescence (IF) image for anti-CD44 antibody (CD44) (ABIN659120) CD44 antibody confocal immunofluorescent analysis with hela cell. 0.01 mg/ml primary...
Flow Cytometry (FACS) image for anti-CD44 antibody (CD44) (ABIN659120) CD44 Antibody flow cytometric analysis of Hela cells (right histogram) compared to a...
Background publications da Cunha, Oliveira, Wen et al.: "De novo expression of CD44 variants in sporadic and hereditary gastric cancer." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 90, Issue 11, pp. 1604-14, 2010 (PubMed).

Somasunderam, Thiviyanathan, Tanaka et al.: "Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of human CD44." in: Biochemistry, Vol. 49, Issue 42, pp. 9106-12, 2010 (PubMed).

Wolny, Banerji, Gounou et al.: "Analysis of CD44-hyaluronan interactions in an artificial membrane system: insights into the distinct binding properties of high and low molecular weight hyaluronan." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 30170-80, 2010 (PubMed).