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Details for Product No. ABIN659120

CD44 (CD44) antibody

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Antigen
Synonyms CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, AU023126, AW121933, AW146109, HERMES, Ly-24, Pgp-1, CD44A, METAA, RHAMM
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN659120
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This CD44 monoclonal antibody is generated from mouse immunized with CD44 recombinant protein.
Clone Hermes-3
Isotype IgG2a, kappa
Specificity This CD44 monoclonal antibody is generated from mouse immunized with CD44 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name CD44
Background The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Synonyms: LHR, MDU2, MDU3, MIC4,CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD_antigen=CD44, Flags: Precursor
Pathways: Hematopoietic cell lineage, ECM-receptor interaction, Shigellosis
Molecular Weight 81,538 Da
Gene ID 960
UniProt P16070
Research Area Cell Structure
Application Notes Recommend dilutions: WB : 1:100-500,IHC : 1:10-50,IF : 1:10-50,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Wolny, Banerji, Gounou et al.: "Analysis of CD44-hyaluronan interactions in an artificial membrane system: insights into the distinct binding properties of high and low molecular weight hyaluronan." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 30170-80, 2010 (PubMed).

Somasunderam, Thiviyanathan, Tanaka et al.: "Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of human CD44." in: Biochemistry, Vol. 49, Issue 42, pp. 9106-12, 2010 (PubMed).

da Cunha, Oliveira, Wen et al.: "De novo expression of CD44 variants in sporadic and hereditary gastric cancer." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 90, Issue 11, pp. 1604-14, 2010 (PubMed).

Alternatives for antigen "CD44 (CD44)", type "Antibodies"
Hosts (528), (198), (159), (8), (2), (1), (1)
Reactivities (619), (317), (142), (93), (73), (59), (38), (19), (13), (13), (11), (9), (8), (3), (3), (1), (1), (1), (1)
Applications (583), (286), (228), (179), (129), (127), (107), (74), (45), (39), (29), (13), (6), (6), (5), (5), (3), (3), (2), (1), (1), (1), (1), (1)
Conjugates (150), (85), (57), (28), (18), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (26), (22), (16), (15), (12), (12), (10), (8), (6), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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