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LIN28A antibody (N-Term)

LIN28A Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783322
  • Target See all LIN28A Antibodies
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    Binding Specificity
    • 15
    • 9
    • 9
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-5, N-Term
    Reactivity
    • 95
    • 28
    • 27
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 79
    • 18
    Rabbit
    Clonality
    • 75
    • 22
    Polyclonal
    Conjugate
    • 47
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LIN28A antibody is un-conjugated
    Application
    • 62
    • 38
    • 24
    • 19
    • 16
    • 14
    • 13
    • 13
    • 9
    • 7
    • 6
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    M-G-S-V-S
    Specificity
    This antibody detects endogenous levels of total Lin28 protein.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse, Rat
    Purification
    Affinity-chromatography using epitope-specific peptide
    Immunogen
    Peptide sequence around aa. 1~5 derived from Human Lin28
    Top Product
    Discover our top product LIN28A Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store (in aliquots) at -20 °C.
  • Target
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    Alternative Name
    LIN28 (LIN28A Products)
    Background
    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.Synonyms: CSDD1, LIN-28, LIN28A, Lin-28 homolog A, ZCCHC1
    Molecular Weight
    26 kDa
    Gene ID
    79727
    NCBI Accession
    NP_078950
    UniProt
    Q9H9Z2
    Pathways
    Stem Cell Maintenance
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