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Details for Product No. ABIN783322

Lin-28 Homolog A (C. Elegans) (LIN28A) (AA 1-5), (N-Term) antibody

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Antigen
Synonyms Lin28, csdd1, lin-28, lin28, zcchc1, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, AL024421, ENSMUSG00000070700, Gm10299, Lin-28, Tex17, RGD1566408, sb:cb650, zgc:55584
Epitope
»Alternatives AA 1-5, N-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN783322
Quantity 0.1 mL
Price
297.00 $   Plus shipping costs $45.00
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Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen Peptide sequence around aa. 1~5 derived from Human Lin28
Sequence M-G-S-V-S
Specificity This antibody detects endogenous levels of total Lin28 protein. Species Reactivity: Tested: Human, Mouse, Rat
Purification Affinity-chromatography using epitope-specific peptide

Target Details

Application Details Handling References Alternatives back to top
Alternative Name LIN28
Background Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.
Alternate names: CSDD1, LIN-28, LIN28A, Lin-28 homolog A, ZCCHC1
Molecular Weight 26 kDa
Gene ID 79727
NCBI Accession NP_078950
UniProt Q9H9Z2

Application Details

Target Details Handling References Alternatives back to top
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months

References

Target Details Application Details Handling Alternatives back to top
Background publications Heo, Joo, Cho et al.: "Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA." in: Molecular cell, Vol. 32, Issue 2, pp. 276-84, 2008 (PubMed).

Viswanathan, Powers, Einhorn et al.: "Lin28 promotes transformation and is associated with advanced human malignancies." in: Nature genetics, Vol. 41, Issue 7, pp. 843-8, 2009 (PubMed).

Heo, Joo, Kim et al.: "TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation." in: Cell, Vol. 138, Issue 4, pp. 696-708, 2009 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Lin-28 Homolog A (C. Elegans) (LIN28A)", type "Antibodies"
Hosts (46), (20)
Reactivities (63), (31), (21), (14), (14), (2), (1), (1)
Applications (54), (31), (18), (17), (14), (10), (9), (7), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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